Literature DB >> 31034729

Diterpene Biosynthesis in Actinomycetes: Studies on Cattleyene Synthase and Phomopsene Synthase.

Jan Rinkel1, Simon T Steiner1, Jeroen S Dickschat1.   

Abstract

Three diterpene synthases from actinomycetes have been studied. The first enzyme from Streptomyces cattleya produced the novel compound cattleyene. The other two enzymes from Nocardia testacea and Nocardia rhamnosiphila were identified as phomopsene synthases. The cyclisation mechanism of cattleyene synthase and the EIMS fragmentation mechanism of its product were extensively studied by incubation experiments with isotopically labelled precursors. Oxidative transformations expanded the chemical space of these unique diterpenes.
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  NMR spectroscopy; enzyme mechanisms; isotopes; ozonolysis; terpenes

Year:  2019        PMID： 31034729     DOI： 10.1002/anie.201902950

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  9 in total

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2.  Two Diterpene Synthases from Chryseobacterium: Chryseodiene Synthase and Wanjudiene Synthase.

Authors:  Lukas Lauterbach; Bernd Goldfuss; Jeroen S Dickschat
Journal:  Angew Chem Int Ed Engl       Date:  2020-05-18       Impact factor: 15.336

3.  A Family of Related Fungal and Bacterial Di- and Sesterterpenes: Studies on Fusaterpenol and Variediene.

Authors:  Jan Rinkel; Simon T Steiner; Guangkai Bian; Rong Chen; Tiangang Liu; Jeroen S Dickschat
Journal:  Chembiochem       Date:  2019-11-07       Impact factor: 3.164

4.  An Unusual Skeletal Rearrangement in the Biosynthesis of the Sesquiterpene Trichobrasilenol from Trichoderma.

Authors:  Keiichi Murai; Lukas Lauterbach; Kazuya Teramoto; Zhiyang Quan; Lena Barra; Tsuyoshi Yamamoto; Kenichi Nonaka; Kazuro Shiomi; Makoto Nishiyama; Tomohisa Kuzuyama; Jeroen S Dickschat
Journal:  Angew Chem Int Ed Engl       Date:  2019-09-09       Impact factor: 15.336

5.  CryoEM analysis of small plant biocatalysts at sub-2 Å resolution.

Authors:  Nicole Dimos; Carl P O Helmer; Andrea M Chánique; Markus C Wahl; Robert Kourist; Tarek Hilal; Bernhard Loll
Journal:  Acta Crystallogr D Struct Biol       Date:  2022-01-01       Impact factor: 7.652

6.  Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes.

Authors:  Baiying Xing; Houchao Xu; Annan Li; Tingting Lou; Meng Xu; Kaibiao Wang; Zhengren Xu; Jeroen S Dickschat; Donghui Yang; Ming Ma
Journal:  Angew Chem Int Ed Engl       Date:  2022-08-01       Impact factor: 16.823

Review 7.  Current understanding and biotechnological application of the bacterial diterpene synthase CotB2.

Authors:  Ronja Driller; Daniel Garbe; Norbert Mehlmer; Monika Fuchs; Keren Raz; Dan Thomas Major; Thomas Brück; Bernhard Loll
Journal:  Beilstein J Org Chem       Date:  2019-10-02       Impact factor: 2.883

8.  Revision of the Cyclisation Mechanism for the Diterpene Spiroviolene and Investigations of Its Mass Spectrometric Fragmentation.

Authors:  Houchao Xu; Jeroen S Dickschat
Journal:  Chembiochem       Date:  2020-11-10       Impact factor: 3.164

Review 9.  Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010-2020).

Authors:  Fa-Lei Zhang; Tao Feng
Journal:  J Fungi (Basel)       Date:  2022-02-28
  9 in total

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