Jinxia Fiona Yao1, James H Wang1, Ho-Ching Shawn Yang1, Zhenhu Liang1,2, Aaron A Cohen-Gadol3, Vitaliy L Rayz1, Yunjie Tong1. 1. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA. 2. Institute of Electrical Engineering, Yanshan University, Yanshan, China. 3. Indiana University School of Medicine, Department of Neurosurgery and Goodman Campbell Brain and Spine, Indianapolis, Indiana, USA.
Abstract
BACKGROUND: The systemic low-frequency oscillation (sLFO) functional (f)MRI signals extracted from the internal carotid artery (ICA) and the superior sagittal sinus (SSS) are found to have valuable physiological information. PURPOSE: 1) To further develop and validate a method utilizing these signals to measure the delay times from the ICAs and the SSS. 2) To establish the delay time as an effective perfusion biomarker that associates with cerebral circulation time (CCT). 3) To explore within subject variations, and the effects of gender and age on the delay times. STUDY TYPE: Prospective. SUBJECTS: In all, 100 healthy adults (Human Connectome Project [HCP], age range 22-36 years, 54 females and 46 males), 56 healthy children (Adolescent Brain Cognitive Development project) were included. FIELD STRENGTH/SEQUENCE: Echo planar imaging (EPI) sequence at 3T. ASSESSMENT: The sLFO fMRI signals from the ICAs and the SSSs were extracted from the resting state fMRI data. The maximum cross-correlation coefficients and their corresponding delay times were calculated. The gender and age differences of delay times were assessed statistically. STATISTICAL TESTS: T-tests were conducted to measure the gender differences. The Kruskal-Wallis test was used to detect age differences. RESULTS: Consistent and robust results were found from 80% of the 400 HCP scans included. Negative correlations (-0.67) between the ICA and the SSS signals were found with the ICA signal leading the SSS signal by ∼5 sec. Within subject variation was 2.23 sec at the 5% significance level. The delay times were not significantly different between genders (P = 0.9846, P = 0.2288 for the left and right ICA, respectively). Significantly shorter delay times (4.3 sec) were found in the children than in the adults (P < 0.01). DATA CONCLUSION: We have shown that meaningful perfusion information (ie, CCT) can be derived from the sLFO fMRI signals of the large blood vessels. LEVEL OF EVIDENCE: 1 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1504-1513.
BACKGROUND: The systemic low-frequency oscillation (sLFO) functional (f)MRI signals extracted from the internal carotid artery (ICA) and the superior sagittal sinus (SSS) are found to have valuable physiological information. PURPOSE: 1) To further develop and validate a method utilizing these signals to measure the delay times from the ICAs and the SSS. 2) To establish the delay time as an effective perfusion biomarker that associates with cerebral circulation time (CCT). 3) To explore within subject variations, and the effects of gender and age on the delay times. STUDY TYPE: Prospective. SUBJECTS: In all, 100 healthy adults (Human Connectome Project [HCP], age range 22-36 years, 54 females and 46 males), 56 healthy children (Adolescent Brain Cognitive Development project) were included. FIELD STRENGTH/SEQUENCE: Echo planar imaging (EPI) sequence at 3T. ASSESSMENT: The sLFO fMRI signals from the ICAs and the SSSs were extracted from the resting state fMRI data. The maximum cross-correlation coefficients and their corresponding delay times were calculated. The gender and age differences of delay times were assessed statistically. STATISTICAL TESTS: T-tests were conducted to measure the gender differences. The Kruskal-Wallis test was used to detect age differences. RESULTS: Consistent and robust results were found from 80% of the 400 HCP scans included. Negative correlations (-0.67) between the ICA and the SSS signals were found with the ICA signal leading the SSS signal by ∼5 sec. Within subject variation was 2.23 sec at the 5% significance level. The delay times were not significantly different between genders (P = 0.9846, P = 0.2288 for the left and right ICA, respectively). Significantly shorter delay times (4.3 sec) were found in the children than in the adults (P < 0.01). DATA CONCLUSION: We have shown that meaningful perfusion information (ie, CCT) can be derived from the sLFO fMRI signals of the large blood vessels. LEVEL OF EVIDENCE: 1 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1504-1513.
Authors: Stephan Joachim Schreiber; Uwe Franke; Florian Doepp; Elda Staccioli; Kamil Uludag; José Manuel Valdueza Journal: Ultrasound Med Biol Date: 2002-04 Impact factor: 2.998
Authors: Aleksandr Rayshubskiy; Teresa J Wojtasiewicz; Charles B Mikell; Matthew B Bouchard; Dmitriy Timerman; Brett E Youngerman; Robert A McGovern; Marc L Otten; Peter Canoll; Guy M McKhann; Elizabeth M C Hillman Journal: Neuroimage Date: 2013-11-01 Impact factor: 6.556
Authors: Can Wu; Amir R Honarmand; Susanne Schnell; Ryan Kuhn; Samantha E Schoeneman; Sameer A Ansari; James Carr; Michael Markl; Ali Shaibani Journal: J Am Heart Assoc Date: 2016-01-04 Impact factor: 5.501
Authors: Bradley Fitzgerald; Jinxia Fiona Yao; Thomas M Talavage; Lia M Hocke; Blaise deB Frederick; Yunjie Tong Journal: Sci Rep Date: 2021-03-26 Impact factor: 4.379