Lia M Hocke1,2, Yunjie Tong1,3, Kimberly P Lindsey1,3, Blaise de B Frederick1,3. 1. McLean Hospital, Belmont, Massachusetts, USA. 2. Tufts Biomedical Engineering Department, Medford, Massachusetts, USA. 3. Harvard Medical School Department of Psychiatry, Boston, Massachusetts, USA.
Abstract
PURPOSE: Functional MRI (fMRI) blood-oxygen level-dependent (BOLD) signals result not only from neuronal activation, but also from nonneuronal physiological processes. These changes, especially in the low-frequency domain (0.01-0.2 Hz), can significantly confound inferences about neuronal processes. It is crucial to effectively identify these nuisance low-frequency oscillations (LFOs). METHOD: A high temporal resolution (repetition time, ∼0.5 s) fMRI resting state study was conducted with simultaneous physiological measurements to compare LFOs measured directly by near-infrared spectroscopy (NIRS) in the periphery and three methods that model LFOs from the respiration or cardiac signal: 1) the respiration volume per time (RVT), 2) the respiratory variation (RVRRF), and 3) the cardiac variation method (HRCRF). The LFO noise regressors from these methods were compared temporally and spatially as well as in their denoising efficiency. RESULTS: Methods were not highly correlated with one another, temporally or spatially. The set of two NIRS LFOs combined explained over 13% of BOLD signal variance and explained equal or more variance than HRCRF and RVRRF or RVT combined (in 14 of 16 participants). CONCLUSION: LFOs collected using NIRS in the periphery contain distinct temporal and spatial information about the LFOs in BOLD fMRI that is not contained in current low-frequency denoising methods derived from respiration and cardiac pulsation. Magn Reson Med 76:1697-1707, 2016.
PURPOSE: Functional MRI (fMRI) blood-oxygen level-dependent (BOLD) signals result not only from neuronal activation, but also from nonneuronal physiological processes. These changes, especially in the low-frequency domain (0.01-0.2 Hz), can significantly confound inferences about neuronal processes. It is crucial to effectively identify these nuisance low-frequency oscillations (LFOs). METHOD: A high temporal resolution (repetition time, ∼0.5 s) fMRI resting state study was conducted with simultaneous physiological measurements to compare LFOs measured directly by near-infrared spectroscopy (NIRS) in the periphery and three methods that model LFOs from the respiration or cardiac signal: 1) the respiration volume per time (RVT), 2) the respiratory variation (RVRRF), and 3) the cardiac variation method (HRCRF). The LFO noise regressors from these methods were compared temporally and spatially as well as in their denoising efficiency. RESULTS: Methods were not highly correlated with one another, temporally or spatially. The set of two NIRS LFOs combined explained over 13% of BOLD signal variance and explained equal or more variance than HRCRF and RVRRF or RVT combined (in 14 of 16 participants). CONCLUSION:LFOs collected using NIRS in the periphery contain distinct temporal and spatial information about the LFOs in BOLD fMRI that is not contained in current low-frequency denoising methods derived from respiration and cardiac pulsation. Magn Reson Med 76:1697-1707, 2016.
Authors: C Triantafyllou; R D Hoge; G Krueger; C J Wiggins; A Potthast; G C Wiggins; L L Wald Journal: Neuroimage Date: 2005-05-15 Impact factor: 6.556
Authors: Stephen M Smith; Mark Jenkinson; Mark W Woolrich; Christian F Beckmann; Timothy E J Behrens; Heidi Johansen-Berg; Peter R Bannister; Marilena De Luca; Ivana Drobnjak; David E Flitney; Rami K Niazy; James Saunders; John Vickers; Yongyue Zhang; Nicola De Stefano; J Michael Brady; Paul M Matthews Journal: Neuroimage Date: 2004 Impact factor: 6.556
Authors: Steen Moeller; Essa Yacoub; Cheryl A Olman; Edward Auerbach; John Strupp; Noam Harel; Kâmil Uğurbil Journal: Magn Reson Med Date: 2010-05 Impact factor: 4.668
Authors: Logan T Dowdle; Geoffrey Ghose; Clark C C Chen; Kamil Ugurbil; Essa Yacoub; Luca Vizioli Journal: Prog Neurobiol Date: 2021-09-04 Impact factor: 11.685
Authors: Ahmed A Khalil; Kersten Villringer; Vivien Filleböck; Jiun-Yiing Hu; Andrea Rocco; Jochen B Fiebach; Arno Villringer Journal: J Cereb Blood Flow Metab Date: 2018-10-18 Impact factor: 6.200