Literature DB >> 3103442

Difluoromethylornithine, an effective new treatment of Gambian trypanosomiasis. Results in five patients.

H Taelman, P J Schechter, L Marcelis, J Sonnet, G Kazyumba, J Dasnoy, K D Haegele, A Sjoerdsma, M Wery.   

Abstract

Recent studies have shown DL-alpha-difluoromethylornithine (eflornithine), an inhibitor of polyamine biosynthesis, to be curative in various Trypanosoma species infections of laboratory animals. Five patients are described with Gambian trypanosomiasis treated in Belgium with difluoromethylornithine, using various intravenous and oral dosage schedules. Three patients had late-stage and two had early-stage disease. Difluoromethylornithine treatment was associated with clearing of parasites from blood within one to four days, a trend towards normalization of all altered biologic values associated with the disease, and marked amelioration of clinical symptoms. Side effects of difluoromethylornithine, including loose stools in three patients and both anemia, and a decrease in auditory acuity in one patient, were mild, transient, and never required interruption of drug treatment. The presence of difluoromethylornithine in cerebrospinal fluid, determined in three patients, demonstrated that difluoromethylornithine penetrates into the central nervous system. In three patients, follow-up of at least 24 months after treatment demonstrated a continued healthy state without evidence of relapse. These promising, albeit preliminary, results of difluoromethylornithine therapy, even in patients with central nervous system involvement, indicate that extended clinical trials are warranted to determine the optimal dosage regimen in patients with early- and late-stage disease.

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Year:  1987        PMID: 3103442     DOI: 10.1016/0002-9343(87)90107-0

Source DB:  PubMed          Journal:  Am J Med        ISSN: 0002-9343            Impact factor:   4.965


  10 in total

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Authors:  E Zweygarth; D Röttcher
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Authors:  I Van Bogaert; A Haemers
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5.  Trypanosoma cruzi has not lost its S-adenosylmethionine decarboxylase: characterization of the gene and the encoded enzyme.

Authors:  K Persson; L Aslund; B Grahn; J Hanke; O Heby
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Review 6.  Drug treatment of tropical parasitic infections: recent achievements and developments.

Authors:  I Stephenson; M Wiselka
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Review 7.  The natural progression of Gambiense sleeping sickness: what is the evidence?

Authors:  Francesco Checchi; João A N Filipe; Michael P Barrett; Daniel Chandramohan
Journal:  PLoS Negl Trop Dis       Date:  2008-12-23

8.  The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain.

Authors:  Lisa Sanderson; Murat Dogruel; Jean Rodgers; Barbara Bradley; Sarah Ann Thomas
Journal:  J Neurochem       Date:  2008-09-24       Impact factor: 5.372

9.  The death and life of the resurrection drug.

Authors:  Charles Ebikeme
Journal:  PLoS Negl Trop Dis       Date:  2014-07-10

Review 10.  The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History.

Authors:  Harry P De Koning
Journal:  Trop Med Infect Dis       Date:  2020-01-19
  10 in total

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