Literature DB >> 2505225

Eflornithine. A new drug in the treatment of sleeping sickness.

I Van Bogaert1, A Haemers.   

Abstract

Eflornithine (alpha-difluoromethylornithine; DFMO) is a recently developed drug against African trypanosomiasis (sleeping sickness). After a short description of trypanosomiasis and the current treatment, the mechanism of action of eflornithine is discussed, some clinical data is given and attention is paid to recently discovered analogues of eflornithine. Some examples of combination therapy with eflornithine and possible applications are mentioned.

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Year:  1989        PMID： 2505225     DOI： 10.1007/bf02110252

Source DB:  PubMed          Journal:  Pharm Weekbl Sci        ISSN： 0167-6555


  38 in total

1.  Inhibition of polyamine biosynthesis by alpha-difluoromethylornithine in African trypanosomes and Pneumocystis carinii as a basis of chemotherapy: biochemical and clinical aspects.

Authors:  P P McCann; C J Bacchi; A B Clarkson; P Bey; A Sjoerdsma; P J Schecter; P D Walzer; J L Barlow
Journal:  Am J Trop Med Hyg       Date:  1986-11       Impact factor: 2.345

2.  Uptake of alpha-difluoromethylornithine by Trypanosoma brucei brucei.

Authors:  A J Bitonti; C J Bacchi; P P McCann; A Sjoerdsma
Journal:  Biochem Pharmacol       Date:  1986-01-15       Impact factor: 5.858

3.  Impairment of macrophage function by inhibitors of ornithine decarboxylase activity.

Authors:  F Kierszenbaum; J J Wirth; P P McCann; A Sjoerdsma
Journal:  Infect Immun       Date:  1987-10       Impact factor: 3.441

Review 4.  Metabolism and function of polyamines.

Authors:  M A Grillo
Journal:  Int J Biochem       Date:  1985

5.  Difluoromethylornithine, an effective new treatment of Gambian trypanosomiasis.

Authors:  G Scalabrino
Journal:  Am J Med       Date:  1987-11       Impact factor: 4.965

Review 6.  [A new molecule in antiparasitic therapy: alpha-difluoromethylornithine].

Authors:  Y Furet; T H Duong; C Combescot; M Breteau
Journal:  Pathol Biol (Paris)       Date:  1987-04

7.  Treatment and prophylaxis for Pneumocystis carinii pneumonia.

Authors:  W T Hughes
Journal:  Parasitol Today       Date:  1987-11

8.  Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.

Authors:  A B Clarkson; C J Bacchi; G H Mellow; H C Nathan; P P McCann; A Sjoerdsma
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

9.  Catalytic irreversible inhibition of bacterial and plant arginine decarboxylase activities by novel substrate and product analogues.

Authors:  A J Bitonti; P J Casara; P P McCann; P Bey
Journal:  Biochem J       Date:  1987-02-15       Impact factor: 3.857

10.  Analogs of diaminopimelic acid as inhibitors of meso-diaminopimelate decarboxylase from Bacillus sphaericus and wheat germ.

Authors:  J G Kelland; L D Arnold; M M Palcic; M A Pickard; J C Vederas
Journal:  J Biol Chem       Date:  1986-10-05       Impact factor: 5.157
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  2 in total

Review 1.  Polyamines and Their Role in Virus Infection.

Authors:  Bryan C Mounce; Michelle E Olsen; Marco Vignuzzi; John H Connor
Journal:  Microbiol Mol Biol Rev       Date:  2017-09-13       Impact factor: 11.056

Review 2.  Amino Acid Based Antimicrobial Agents - Synthesis and Properties.

Authors:  Michał G Nowak; Andrzej S Skwarecki; Maria J Milewska
Journal:  ChemMedChem       Date:  2021-10-01       Impact factor: 3.540
  2 in total

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