| Literature DB >> 31033382 |
Jessica De Leon1, Maria Luisa Mandelli1, Amber Nolan1, Zachary A Miller1, Christie Mead2, Christa Watson1, Ariane E Welch1, Maya L Henry3, Viktoriya Bourakova1, Renaud La Joie1, Lynn P Bajorek1, Lea Grinberg1, Gil Rabinovici1, Bruce L Miller1, Maria Luisa Gorno-Tempini1.
Abstract
A 66-year-old woman presented with agrammatism and apraxia of speech, meeting criteria for non-fluent/agrammatic variant primary progressive aphasia (nfvPPA). However, three years later, she developed frontal/executive, short-term phonological memory, visuospatial, and visual memory deficits suggesting involvement of multiple brain networks. Multimodal neuroimaging showed damage of both fronto-striatal and posterior brain regions. She was found to have multiple pathological processes: corticobasal degeneration (CBD), Alzheimer's disease (AD), and TAR DNA-binding protein (TDP)-43 type A. We hypothesize that cognitive and neuroimaging findings consistent with damage to multiple brain networks, each associated with vulnerability to certain molecular disease subtypes, could indicate mixed pathology.Entities:
Keywords: Alzheimer’s disease neuropathology; Non-fluent agrammatic primary progressive aphasia; TDP-43 type A neuropathology; corticobasal degeneration; syntax network
Mesh：
Year: 2019 PMID： 31033382 PMCID： PMC6759324 DOI： 10.1080/13554794.2019.1609522
Source DB: PubMed Journal: Neurocase ISSN： 1355-4794 Impact factor: 0.881