| Literature DB >> 31029658 |
Anaëlle Doerflinger1, Nam Nguyen Quang2, Edmond Gravel1, Frédéric Ducongé3, Eric Doris4.
Abstract
In this study, a "click and hybridization" strategy was developed for the functionalization of polydiacetylene micelles with a targeting aptamer ligand. Decoration of the nanocarriers with an anti-Annexin A2 sequence efficiently triggered enhanced internalization of the functionalized micelles in the MCF-7 cell line, with a marked increase compared to control micelles.Entities:
Keywords: Aptamer; Click chemistry; Conjugation; Micelle; Nanomedicine
Mesh：
Substances：
Year: 2019 PMID： 31029658 DOI： 10.1016/j.ijpharm.2019.04.071
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875