Shajedul Islam1, Malsantha Muthumala2, Hirofumi Matsuoka1, Osamu Uehara1,3, Yasuhiro Kuramitsu3, Itsuo Chiba1, Yoshihiro Abiko4. 1. Division of Disease Control and Molecular Epidemiology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Ishikari, Hokkaido, 061-0293, Japan. 2. Department of Oral and Maxillofacial Surgery, Army Hospital, Colombo, Sri Lanka. 3. Research Institute of Cancer Prevention, Health Sciences University of Hokkaido, Ishikari, Hokkaido, 061-0293, Japan. 4. Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa-Tobetsu, Ishikari, Hokkaido, 061-0293, Japan. yoshi-ab@hoku-iryo-u.ac.jp.
Abstract
PURPOSE OF REVIEW: The roles of the components of betel quid in oral carcinogenesis remain unclear. The purpose of the present review is to highlight the effect of each component of betel quid and to discuss the synergistic effects of other carcinogens along with betel quid in the development of oral cancer in habitual betel quid chewers. RECENT FINDINGS: Betel quid may synergistically participate in carcinogenesis by disrupting the compositions of oral microbiota, accompanied by endotoxins secretion and reactive oxygen species (ROS) production. Microbiome dysbiosis mediated by synergistic effects of betel quid chewing, smoking, and alcohol drinking is possibly linked to oral carcinogenesis, which is firstly discussed in this report. Betel quid and other carcinogenic components, mainly contribute to downregulate the antioxidant proteins and lead to the induction of ROS. The elimination of ROS may prove most effective chemoprevention for betel quid-mediated oral carcinogenesis.
PURPOSE OF REVIEW: The roles of the components of betel quid in oral carcinogenesis remain unclear. The purpose of the present review is to highlight the effect of each component of betel quid and to discuss the synergistic effects of other carcinogens along with betel quid in the development of oral cancer in habitual betel quid chewers. RECENT FINDINGS: Betel quid may synergistically participate in carcinogenesis by disrupting the compositions of oral microbiota, accompanied by endotoxins secretion and reactive oxygen species (ROS) production. Microbiome dysbiosis mediated by synergistic effects of betel quid chewing, smoking, and alcohol drinking is possibly linked to oral carcinogenesis, which is firstly discussed in this report. Betel quid and other carcinogenic components, mainly contribute to downregulate the antioxidant proteins and lead to the induction of ROS. The elimination of ROS may prove most effective chemoprevention for betel quid-mediated oral carcinogenesis.
Authors: Pangzhen Zhang; Nathaniel Quan En Chua; Simon Dang; Ashleigh Davis; Kah Wee Chong; Stephen S Prime; Nicola Cirillo Journal: Int J Mol Sci Date: 2022-01-31 Impact factor: 5.923