Wioletta Wujcicka1,2, Agnieszka Zając3, Grzegorz Stachowiak4. 1. Scientific Laboratory of the Center of Medical Laboratory Diagnostics and Screening, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland. 2. Department of Obstetrics, Perinatology and Gynecology, Polish Mother's Memorial Hospital - Research Institute, Medical University of Lodz, Lodz, Poland. 3. Department of Operative Gynecology and Gynecologic Oncology, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland. 4. Department of Operative Gynecology and Gynecologic Oncology, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland gstach23@interia.pl.
Abstract
BACKGROUND/AIM: The aim of this study was to determine the joint effect of single nucleotide polymorphisms (SNPs) of MDM2, TP53, and CDKN2A (P14ARF) genes on the onset and course of endometrial cancer (EC) in postmenopausal women. MATERIALS AND METHODS: The study group consisted of 144 EC women and 50 non-cancer controls. MDM2 rs22279744, TP53 rs1042522, and P14ARF rs3088440, rs3731217, and rs3731245 SNPs were analysed. RESULTS: The double-SNP combinations T-C, T-T, or T-G in MDM2 SNP 309 and P14ARF polymorphisms decreased EC risk. The triple-SNP combinations T-C-T, T-C-G, or T-T-G in MDM2 SNP and two P14ARF polymorphisms decreased EC risk. The multiple-SNP combination T-C-T-G in MDM2 and three P14ARF polymorphisms decreased EC risk. The G-Arg-C-T-G carriers were at increased EC risk, while the T-Arg-C-T-G carriers were at decreased EC risk. CONCLUSION: MDM2 SNP309 plays a role in EC onset in postmenopausal women. Copyright
BACKGROUND/AIM: The aim of this study was to determine the joint effect of single nucleotide polymorphisms (SNPs) of MDM2, TP53, and CDKN2A (P14ARF) genes on the onset and course of endometrial cancer (EC) in postmenopausal women. MATERIALS AND METHODS: The study group consisted of 144 EC women and 50 non-cancer controls. MDM2rs22279744, TP53rs1042522, and P14ARFrs3088440, rs3731217, and rs3731245 SNPs were analysed. RESULTS: The double-SNP combinations T-C, T-T, or T-G in MDM2 SNP 309 and P14ARF polymorphisms decreased EC risk. The triple-SNP combinations T-C-T, T-C-G, or T-T-G in MDM2 SNP and two P14ARF polymorphisms decreased EC risk. The multiple-SNP combination T-C-T-G in MDM2 and three P14ARF polymorphisms decreased EC risk. The G-Arg-C-T-G carriers were at increased EC risk, while the T-Arg-C-T-G carriers were at decreased EC risk. CONCLUSION:MDM2 SNP309 plays a role in EC onset in postmenopausal women. Copyright
Authors: Wioletta Wujcicka; Agnieszka Zajac; Krzysztof Szyllo; Beata Smolarz; Hanna Romanowicz; Grzegorz Stachowiak Journal: In Vivo Date: 2020 Mar-Apr Impact factor: 2.155
Authors: C P Campello; M F B Lima-Silva; E L S de Lima; G R S Nunes; H A M Silva; E Dellalibera; L R P B de Britto; C A A Lemos; M T C Muniz Journal: Braz J Med Biol Res Date: 2022-03-11 Impact factor: 2.590
Authors: Jinze Li; Ying Ma; Jackie K Paquette; Amanda C Richards; Matthew A Mulvey; James F Zachary; Cory Teuscher; Janis J Weis Journal: PLoS Pathog Date: 2022-03-24 Impact factor: 6.823