Wioletta Wujcicka1,2, Agnieszka Zajac3, Krzysztof Szyllo3, Beata Smolarz4, Hanna Romanowicz5, Grzegorz Stachowiak3. 1. Scientific Laboratory of the Center of Medical Laboratory Diagnostics and Screening, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland wwujcicka@yahoo.com. 2. Department of Obstetrics, Perinatology and Gynecology, Polish Mother's Memorial Hospital - Research Institute, Department of Gynecology and Obstetrics, Medical University of Lodz, Lodz, Poland. 3. Department of Operative Gynecology and Gynecologic Oncology, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland. 4. Laboratory of Cancer Genetics of the Department of Clinical Pathomorphology, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland. 5. Department of Clinical Pathomorphology, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
Abstract
BACKGROUND/AIM: This research was aimed to evaluate the association between three selected single nucleotide polymorphisms (SNPs) within the CDKN2A (P14ARF) tumour suppressor gene and the incidence of endometrial cancer (EC) in postmenopausal women. PATIENTS AND METHODS: The study included 194 postmenopausal women; 144 with EC and 50 non-cancer controls. Genotypes in P14ARF rs3088440, rs3731217 and rs3731245 polymorphisms were assayed using PCR-RFLP and confirmed by sequencing. RESULTS: Regarding the rs3088440 polymorphism, CT, and CT-TT genotypes, were more prevalent among EC patients than in controls (OR=5.55, p=0.023, OR=5.29, p=0.027; and OR=2.92, p=0.023, respectively). The T allele within rs3088440 was more prevalent in EC females than in controls (χ2=4.7, p=0.030). Considering rs3731217, TG and TG-GG genotypes were less prevalent among EC (OR=0.34, p=0.024 or p=0.023; and OR=0.38, p=0.035, respectively). CONCLUSION: Polymorphisms in the CDKN2A gene are associated with EC in postmenopausal women. Copyright
BACKGROUND/AIM: This research was aimed to evaluate the association between three selected single nucleotide polymorphisms (SNPs) within the CDKN2A (P14ARF) tumour suppressor gene and the incidence of endometrial cancer (EC) in postmenopausal women. PATIENTS AND METHODS: The study included 194 postmenopausal women; 144 with EC and 50 non-cancer controls. Genotypes in P14ARFrs3088440, rs3731217 and rs3731245 polymorphisms were assayed using PCR-RFLP and confirmed by sequencing. RESULTS: Regarding the rs3088440 polymorphism, CT, and CT-TT genotypes, were more prevalent among ECpatients than in controls (OR=5.55, p=0.023, OR=5.29, p=0.027; and OR=2.92, p=0.023, respectively). The T allele within rs3088440 was more prevalent in EC females than in controls (χ2=4.7, p=0.030). Considering rs3731217, TG and TG-GG genotypes were less prevalent among EC (OR=0.34, p=0.024 or p=0.023; and OR=0.38, p=0.035, respectively). CONCLUSION: Polymorphisms in the CDKN2A gene are associated with EC in postmenopausal women. Copyright
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