Literature DB >> 31027433

Effect of Irbesartan on AGEs-RAGE and MMPs systems in rat type 2 diabetes myocardial-fibrosis model.

Ye Hongwei1,2, Cao Ruiping1,2, Fang Yingyan3, Zhang Guanjun1, Hu Jie1, Liu Xingyu1, Tang Jie2, Li Zhenghong1, Gao Qin1, Hu Junfeng4, Zhang Heng5.   

Abstract

IMPACT STATEMENT: There are about 425 million diabetes patients (20-79 years) in the world according to the International Diabetes Federation Diabetes Atlas - 8th Edition. The cardiovascular complication is one of the major causes of death in diabetes patients. Myocardial fibrosis is one of the serious pathological changes, so investigating the pathogenesis of myocardial fibrosis has the significant value. Our study aims to investigate the effect of Irbesartan (the angiotensin II receptor antagonist) on the changes of AGE-RAGE system and MMP family components, and analyzes the potential mechanisms in type 2 diabetes-induced myocardial fibrosis. Our results provide the theoretical base for better understanding the pathogenesis in type 2 diabetes-induced myocardial complication. It is useful for clinicians to select the effective therapeutic measures for treatment of type 2 diabetes-induced organ fibrosis.

Entities:  

Keywords:  Irbesartan; Type 2 diabetes mellitus; advanced glycation end products and their receptor system; matrix metalloproteinases pathway; myocardial fibrosis

Mesh：

Substances：

Year:  2019        PMID： 31027433      PMCID： PMC6545694          DOI： 10.1177/1535370219840981

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  43 in total

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Journal:  FEBS J       Date:  2010-11-19       Impact factor: 5.542

2.  Effects of irbesartan on the expression of matrix metalloproteinase-2/tissue inhibitor of metalloproteinase-2 in streptozotocin-induced diabetic rat kidney.

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3.  Structural arrangement of the cardiac collagen fibers of healthy and diabetic dogs.

Authors:  Hildebrando G Benedicto; Pedro P Bombonato; Guido Macchiarelli; Giuseppe Stifano; Isaura M M Prado
Journal:  Microsc Res Tech       Date:  2011-04-11       Impact factor: 2.769

Review 4.  Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases.

Authors:  Marta Ruiz-Ortega; Mónica Rupérez; Vanesa Esteban; Juan Rodríguez-Vita; Elsa Sánchez-López; Giselle Carvajal; Jesús Egido
Journal:  Nephrol Dial Transplant       Date:  2005-11-09       Impact factor: 5.992

5.  Effects of angiotensin receptor blocker on phenotypic alterations of podocytes in early diabetic nephropathy.

Authors:  Hou-Yong Dai; Min Zheng; Ri-Ning Tang; Jie Ni; Kun-Ling Ma; Qing Li; Bi-Cheng Liu
Journal:  Am J Med Sci       Date:  2011-03       Impact factor: 2.378

6.  Angiotensin II-mediated activation of fibrotic pathways through ERK1/2 in rat peritoneal mesothelial cells.

Authors:  Jing-Yuan Xie; Nan Chen; Hong Ren; Wei-Ming Wang
Journal:  Ren Fail       Date:  2010       Impact factor: 2.606

Review 7.  Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications.

Authors:  Zhi You Fang; Johannes B Prins; Thomas H Marwick
Journal:  Endocr Rev       Date:  2004-08       Impact factor: 19.871

Review 8.  Approaches to prevention of cardiovascular complications and events in diabetes mellitus.

Authors:  Sergio Coccheri
Journal:  Drugs       Date:  2007       Impact factor: 9.546

9.  MT1-MMP expression in first-trimester placental tissue is upregulated in type 1 diabetes as a result of elevated insulin and tumor necrosis factor-alpha levels.

Authors:  Ursula Hiden; Elisabeth Glitzner; Marina Ivanisevic; Josip Djelmis; Christian Wadsack; Uwe Lang; Gernot Desoye
Journal:  Diabetes       Date:  2007-10-10       Impact factor: 9.461

Review 10.  Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options.

Authors:  Ronald M Witteles; Michael B Fowler
Journal:  J Am Coll Cardiol       Date:  2008-01-15       Impact factor: 24.094
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  5 in total

1.  Epigallocatechin-3-gallate attenuates myocardial fibrosis in diabetic rats by activating autophagy.

Authors:  Qiang Jia; Rui Yang; Shomaila Mehmood; Yan Li
Journal:  Exp Biol Med (Maywood)       Date:  2022-07-14

2.  [Expression of NLRP1 inflammasomes in myocardial tissue of diabetic rats].

Authors:  Li Rong; Shuo Sun; Feiyu Zhu; Yi Zhao; Qin Gao; Heng Zhang; Bi Tang; Hongju Wang; Pinfang Kang
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2020-01-30

3.  Combination of endothelial progenitor cells and BB-94 significantly alleviates brain damage in a mouse model of diabetic ischemic stroke.

Authors:  Daixuan Zhou; Zhi Huang; Xiaoxi Zhu; Tao Hong; Yuanli Zhao
Journal:  Exp Ther Med       Date:  2021-05-21       Impact factor: 2.447

Review 4.  RAGE Signaling in Melanoma Tumors.

Authors:  Olamide T Olaoba; Sultan Kadasah; Stefan W Vetter; Estelle Leclerc
Journal:  Int J Mol Sci       Date:  2020-11-26       Impact factor: 5.923

Review 5.  Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities.

Authors:  Izabela Tuleta; Nikolaos G Frangogiannis
Journal:  Adv Drug Deliv Rev       Date:  2021-07-29       Impact factor: 17.873
  5 in total

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