Literature DB >> 21484942

Structural arrangement of the cardiac collagen fibers of healthy and diabetic dogs.

Hildebrando G Benedicto1, Pedro P Bombonato, Guido Macchiarelli, Giuseppe Stifano, Isaura M M Prado.   

Abstract

The heart is composed by a specialized muscle, whose form and function are essentials for an adequate work and shows an amount of connective tissue which support and provide insertion for this muscle, whose collagen fibers are responsible for determination of tissue feature. Our objective was to identify the structural arrangement of the heart collagen fibers in dogs. The hearts of the dogs were submitted to the process of the controlled digestion with NaOH solution and observed by scanning electron microscope. Our results showed that the collagen fibers of the endomysial wall have structural arrangement composed by an irregular network with one layer in normal dogs but in diabetic dogs the network acquires a greater amount of the fibers and layers, looking like a "rug" of fibers modifying the relationships of the stress/strain of the tissue. Ahead of the observed results we are able to conclude that exist increase in the amount and thickness of cardiac collagen fibers, beyond the increase of layers and architectural disarrangement in the endomysial wall in the diabetic dogs.
Copyright © 2011 Wiley Periodicals, Inc.

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Year:  2011        PMID: 21484942     DOI: 10.1002/jemt.20988

Source DB:  PubMed          Journal:  Microsc Res Tech        ISSN: 1059-910X            Impact factor:   2.769


  1 in total

1.  Effect of Irbesartan on AGEs-RAGE and MMPs systems in rat type 2 diabetes myocardial-fibrosis model.

Authors:  Ye Hongwei; Cao Ruiping; Fang Yingyan; Zhang Guanjun; Hu Jie; Liu Xingyu; Tang Jie; Li Zhenghong; Gao Qin; Hu Junfeng; Zhang Heng
Journal:  Exp Biol Med (Maywood)       Date:  2019-04-26
  1 in total

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