Literature DB >> 31010925

Intergenerational transmission of the positive effects of physical exercise on brain and cognition.

Kerry R McGreevy1, Patricia Tezanos1, Iria Ferreiro-Villar1, Anna Pallé1, Marta Moreno-Serrano1, Anna Esteve-Codina2, Ismael Lamas-Toranzo3, Pablo Bermejo-Álvarez3, Julia Fernández-Punzano4,5, Alejandro Martín-Montalvo6, Raquel Montalbán7,8, Sacri R Ferrón7,8, Elizabeth J Radford9, Ángela Fontán-Lozano10,11, José Luis Trejo10.   

Abstract

Physical exercise has positive effects on cognition, but very little is known about the inheritance of these effects to sedentary offspring and the mechanisms involved. Here, we use a patrilineal design in mice to test the transmission of effects from the same father (before or after training) and from different fathers to compare sedentary- and runner-father progenies. Behavioral, stereological, and whole-genome sequence analyses reveal that paternal cognition improvement is inherited by the offspring, along with increased adult neurogenesis, greater mitochondrial citrate synthase activity, and modulation of the adult hippocampal gene expression profile. These results demonstrate the inheritance of exercise-induced cognition enhancement through the germline, pointing to paternal physical activity as a direct factor driving offspring's brain physiology and cognitive behavior.

Entities:  

Keywords:  adult hippocampal neurogenesis; cognition traits; intergenerational inheritance; mitochondria; moderate physical exercise

Mesh：

Year:  2019        PMID： 31010925      PMCID： PMC6525532          DOI： 10.1073/pnas.1816781116

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  45 in total

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  12 in total

1.  Intergenerational transmission of the positive effects of physical exercise on brain and cognition.

Authors:  Kerry R McGreevy; Patricia Tezanos; Iria Ferreiro-Villar; Anna Pallé; Marta Moreno-Serrano; Anna Esteve-Codina; Ismael Lamas-Toranzo; Pablo Bermejo-Álvarez; Julia Fernández-Punzano; Alejandro Martín-Montalvo; Raquel Montalbán; Sacri R Ferrón; Elizabeth J Radford; Ángela Fontán-Lozano; José Luis Trejo
Journal:  Proc Natl Acad Sci U S A       Date:  2019-04-22       Impact factor: 11.205

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7.  Is There a Role of Epigenetically Inherited Neurogenesis on Infantile Amnesia? Commentary: Intergenerational Transmission of the Positive Effects of Physical Exercise on Brain and Cognition.

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Journal:  Front Neurosci       Date:  2019-10-11       Impact factor: 4.677

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