Haeun Jang1, Kyong Park2. 1. Department of Food and Nutrition, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk, 38541, Republic of Korea. 2. Department of Food and Nutrition, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk, 38541, Republic of Korea. Electronic address: kypark@ynu.ac.kr.
Abstract
BACKGROUND & AIMS: Previous studies suggest that polyunsaturated fatty acids (PUFAs) may reduce the risk of metabolic diseases, but some have shown ambiguous results. The aim of this study was to systematically evaluate and summarize available evidence on the association between omega-3 and omega-6 PUFA levels and risk of metabolic syndrome (MetS). METHODS: A systematic literature search of articles published until December 2017 was conducted in PubMed, Web of Science, and Cochrane Library databases. Meta-analyses of the highest vs. lowest categories of omega-3 and omega-6 PUFAs were conducted using the random effects models. RESULTS: Thirteen studies (2 case-control, 9 cross-sectional, 1 nested case-control, and 1 prospective cohort) with 36,542 individuals were included. Higher omega-3 PUFA levels in diets or blood were associated with a 26% reduction in the risk of MetS (odds ratio (OR)/relative risk (RR) 0.74, 95% confidence interval (CI) 0.62-0.89). This inverse association was evident among studies with Asian populations (OR/RR 0.69, 95% CI 0.54-0.87), but not among those with American/European populations (OR/RR 0.84, 95% CI 0.55-1.28). Null results were found regarding the association between circulating/dietary omega-6 PUFAs and MetS. CONCLUSION: The present meta-analysis indicates that higher intakes of omega-3 PUFAs, but not omega-6 PUFAs, was associated with lower MetS risk; adding to the current body of evidence on the metabolic health effects of circulating/dietary omega-3 PUFAs.
BACKGROUND & AIMS: Previous studies suggest that polyunsaturated fatty acids (PUFAs) may reduce the risk of metabolic diseases, but some have shown ambiguous results. The aim of this study was to systematically evaluate and summarize available evidence on the association between omega-3 and omega-6PUFA levels and risk of metabolic syndrome (MetS). METHODS: A systematic literature search of articles published until December 2017 was conducted in PubMed, Web of Science, and Cochrane Library databases. Meta-analyses of the highest vs. lowest categories of omega-3 and omega-6 PUFAs were conducted using the random effects models. RESULTS: Thirteen studies (2 case-control, 9 cross-sectional, 1 nested case-control, and 1 prospective cohort) with 36,542 individuals were included. Higher omega-3PUFA levels in diets or blood were associated with a 26% reduction in the risk of MetS (odds ratio (OR)/relative risk (RR) 0.74, 95% confidence interval (CI) 0.62-0.89). This inverse association was evident among studies with Asian populations (OR/RR 0.69, 95% CI 0.54-0.87), but not among those with American/European populations (OR/RR 0.84, 95% CI 0.55-1.28). Null results were found regarding the association between circulating/dietary omega-6 PUFAs and MetS. CONCLUSION: The present meta-analysis indicates that higher intakes of omega-3 PUFAs, but not omega-6 PUFAs, was associated with lower MetS risk; adding to the current body of evidence on the metabolic health effects of circulating/dietary omega-3 PUFAs.
Authors: Timothy D O'Connell; Katherine A Murphy; Naixin Zhang; Sara J Puccini; Chastity L Healy; Brian A Harsch; Michael J Zhang; Gregory C Shearer Journal: Physiology (Bethesda) Date: 2022-08-09
Authors: Anne E Sanders; E Diane Weatherspoon; Brandie M Ehrmann; Paul S Soma; Saame R Shaikh; John S Preisser; Richard Ohrbach; Roger B Fillingim; Gary D Slade Journal: J Pain Date: 2022-04-25 Impact factor: 5.383
Authors: Monica Del C Gomez-Alonso; Anja Kretschmer; Rory Wilson; Liliane Pfeiffer; Ville Karhunen; Ilkka Seppälä; Weihua Zhang; Kirstin Mittelstraß; Simone Wahl; Pamela R Matias-Garcia; Holger Prokisch; Sacha Horn; Thomas Meitinger; Luis R Serrano-Garcia; Sylvain Sebert; Olli Raitakari; Marie Loh; Wolfgang Rathmann; Martina Müller-Nurasyid; Christian Herder; Michael Roden; Mikko Hurme; Marjo-Riitta Jarvelin; Mika Ala-Korpela; Jaspal S Kooner; Annette Peters; Terho Lehtimäki; John C Chambers; Christian Gieger; Johannes Kettunen; Melanie Waldenberger Journal: Clin Epigenetics Date: 2021-01-07 Impact factor: 6.551