| Literature DB >> 35944007 |
Timothy D O'Connell1, Katherine A Murphy1, Naixin Zhang1, Sara J Puccini1, Chastity L Healy1, Brian A Harsch2, Michael J Zhang1, Gregory C Shearer2.
Abstract
A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-polyunsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.Entities:
Keywords: 18-hydroxyeicosapentaenoic acid (18-HEPE); cardiometabolic disease; free fatty acid receptor 4 (Ffar4); heart; specialized proresolving mediators (SPM) ; ω3-polyunsaturated fatty acids (ω3-PUFAs)
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Year: 2022 PMID： 35944007 PMCID： PMC9550565 DOI： 10.1152/physiol.00007.2022
Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221