Literature DB >> 3100883

Interleukin-2 (IL-2) and its receptor.

E L Larsson.   

Abstract

The interleukin-2 (IL-2) receptor system which is responsible for T-cell cycle progression is a unique hormone-receptor system in that both the ligand and the receptor need to be induced. In the present article I will review the biological and molecular characteristics of IL-2 and its receptor, as well as the differential triggering and growth requirements that L3T4+ (T4+) helper and Lyt-2+ (T8+) cytotoxic/suppressor T-cells display to respond. The various mechanisms of regulation operating to restrain clonal IL-2-dependent expansion of normal T-lymphocytes will be discussed.

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Year:  1986        PMID： 3100883     DOI： 10.1007/bf02934999

Source DB:  PubMed          Journal:  Med Oncol Tumor Pharmacother        ISSN： 0736-0118


  58 in total

1.  Long term culture of tumour-specific cytotoxic T cells.

Authors:  S Gillis; K A Smith
Journal:  Nature       Date:  1977-07-14       Impact factor: 49.962

2.  Functional consequences of sheep red blood cell rosetting for human T cells: gain of reactivity to mitogenic factors.

Authors:  E L Larsson; J Andersson; A Coutinho
Journal:  Eur J Immunol       Date:  1978-10       Impact factor: 5.532

3.  Purification and chemical characterization of the receptor for interleukin 2 from activated human T lymphocytes and from a human T-cell lymphoma cell line.

Authors:  D L Urdal; C J March; S Gillis; A Larsen; S K Dower
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205

4.  A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.

Authors:  T Uchiyama; S Broder; T A Waldmann
Journal:  J Immunol       Date:  1981-04       Impact factor: 5.422

5.  Characterization of the human receptor for T-cell growth factor.

Authors:  W J Leonard; J M Depper; R J Robb; T A Waldmann; W C Greene
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

6.  Two distinct factors are required for induction of T-cell growth.

Authors:  E L Larsson; N N Iscove; A Coutinho
Journal:  Nature       Date:  1980-02-14       Impact factor: 49.962

7.  Structure and expression of a cloned cDNA for human interleukin-2.

Authors:  T Taniguchi; H Matsui; T Fujita; C Takaoka; N Kashima; R Yoshimoto; J Hamuro
Journal:  Nature       Date:  1983 Mar 24-30       Impact factor: 49.962

8.  Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.

Authors:  T Yokota; N Arai; F Lee; D Rennick; T Mosmann; K Arai
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

9.  Transient expression of interleukin 2 receptors. Consequences for T cell growth.

Authors:  D A Cantrell; K A Smith
Journal:  J Exp Med       Date:  1983-12-01       Impact factor: 14.307

10.  Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line.

Authors:  S Gillis; J Watson
Journal:  J Exp Med       Date:  1980-12-01       Impact factor: 14.307
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  1 in total

Review 1.  The clinical potential of interleukin-2.

Authors:  R T Oliver
Journal:  Br J Cancer       Date:  1988-10       Impact factor: 7.640
  1 in total

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