Brianna C MacQueen1, Robert D Christensen2, Vickie L Baer3, Diane M Ward4, Gregory L Snow5. 1. Department of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA. Electronic address: brianna.macqueen@hsc.utah.edu. 2. Department of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA; Women and Newborn's Clinical Program, Intermountain Healthcare, Murray, UT, USA; Department of Pediatrics, Division of Hematology/Oncology, University of Utah Health, Salt Lake City, UT, USA. 3. Women and Newborn's Clinical Program, Intermountain Healthcare, Murray, UT, USA. 4. Department of Pathology, University of Utah Health, Salt Lake City, UT, USA. 5. The Statistical Data Center, Intermountain Healthcare, Salt Lake City, UT, USA.
Abstract
OBJECTIVES: Small for gestational age infants (SGA), infants of diabetic mothers (IDM), and very low birth weight infants (VLBW) are at risk for congenital iron deficiency. We evaluated the iron status of SGA, IDM, and VLBW neonates at birth and sought mechanistic explanations in those with iron deficiency. METHODS: This was a prospective study. If congenital iron deficiency was present, maternal iron studies were obtained. When neonates were two weeks old, their iron status was reevaluated. RESULTS: Sixteen of 180 neonates screened were iron deficient at birth. The Body Mass Index of the 16 mothers was high. These mothers often had mild iron deficiency and measurable hepcidin levels. Two weeks after birth, neonates had improved iron measurements. CONCLUSIONS: Among SGA, IDM, and VLBW neonates, maternal obesity is a risk factor for congenital iron deficiency. We speculate that elevated hepcidin levels in obese pregnant women impede iron absorption and interfere with transplacental iron transfer.
OBJECTIVES: Small for gestational age infants (SGA), infants of diabetic mothers (IDM), and very low birth weight infants (VLBW) are at risk for congenital iron deficiency. We evaluated the iron status of SGA, IDM, and VLBW neonates at birth and sought mechanistic explanations in those with iron deficiency. METHODS: This was a prospective study. If congenital iron deficiency was present, maternal iron studies were obtained. When neonates were two weeks old, their iron status was reevaluated. RESULTS: Sixteen of 180 neonates screened were iron deficient at birth. The Body Mass Index of the 16 mothers was high. These mothers often had mild iron deficiency and measurable hepcidin levels. Two weeks after birth, neonates had improved iron measurements. CONCLUSIONS: Among SGA, IDM, and VLBW neonates, maternal obesity is a risk factor for congenital iron deficiency. We speculate that elevated hepcidin levels in obese pregnant women impede iron absorption and interfere with transplacental iron transfer.
Authors: B C MacQueen; R D Christensen; D M Ward; S T Bennett; E A O'Brien; M J Sheffield; V L Baer; G L Snow; K A Weaver Lewis; R E Fleming; J Kaplan Journal: J Perinatol Date: 2016-12-15 Impact factor: 2.521
Authors: Hassan M Yaish; Colin P Farrell; Robert D Christensen; Brianna C MacQueen; Laurie K Jackson; Jesus Trochez-Enciso; Jerry Kaplan; Diane M Ward; Walid K Salah; John D Phillips Journal: Blood Cells Mol Dis Date: 2017-04-09 Impact factor: 3.039
Authors: Timothy M Bahr; Nicholas R Carr; Thomas R Christensen; Jacob Wilkes; Elizabeth A O'Brien; Kendell R German; Robin K Ohls; Diane M Ward; Robert D Christensen Journal: Blood Cells Mol Dis Date: 2021-05-06 Impact factor: 2.372
Authors: Timothy M Bahr; Diane M Ward; Xuan Jia; Robin K Ohls; Kendell R German; Robert D Christensen Journal: Blood Cells Mol Dis Date: 2021-01-06 Impact factor: 2.372
Authors: Paulina S Marell; Sharon E Blohowiak; Michael D Evans; Michael K Georgieff; Pamela J Kling; Phu V Tran Journal: Nutrients Date: 2019-10-16 Impact factor: 5.717