| Literature DB >> 31004736 |
Haroon Khan1, Marcella Reale2, Hammad Ullah3, Antoni Sureda4, Silvia Tejada5, Ying Wang6, Zhang-Jin Zhang7, Jianbo Xiao8.
Abstract
The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. The aim of this review is to focus the significance of p53 signaling pathways and to provide molecular intuitions of dietary polyphenols in chemoprevention by monitoring p53 expression that have a prominent role in tumor suppression.Entities:
Keywords: Anticancer; Chemoresistance; Clinical perspectives; Polyphenols; p53 signaling pathways
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Year: 2019 PMID： 31004736 DOI： 10.1016/j.biotechadv.2019.04.007
Source DB: PubMed Journal: Biotechnol Adv ISSN： 0734-9750 Impact factor: 14.227