Soyeon Kim1, Hyeok-Jae Jang2, Woojae Myung3, Kiwon Kim4, Soojin Cha5, Hyewon Lee6, Sung Kweon Cho7, Beomsu Kim5, Tae Hyon Ha8, Jong-Won Kim9, Doh Kwan Kim10, Eli Ayumi Stahl11, Hong-Hee Won12. 1. Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea; Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea. 2. Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea; Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. 3. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea. Electronic address: wjmyung@snubh.org. 4. Department of Psychiatry, Veteran Health Service Medical Center, Seoul, South Korea. 5. Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea. 6. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea; Institute of Health and Environment, Seoul National University, Seoul, South Korea. 7. Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea; Molecular Genetic Epidemiology Section, National Cancer Institute (NCI), Frederick, MD, USA. 8. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea. 9. Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. 10. Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. 11. Department of Genetics and Genomic Sciences, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 12. Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea. Electronic address: wonhh@skku.edu.
Abstract
BACKGROUND: Psychological distress symptoms are associated with an increased risk of psychiatric disorders and medical illness. Although psychological distress is influenced by environmental factors, such as socioeconomic status, lifetime events, or interpersonal relationships, substantial interindividual variation also exists. However, heritability and genetic determinants of distress are poorly understood. METHODS: In the Korean Genome and Epidemiology Study sample (n = 12,680), we estimated the heritability of individual psychological distress symptoms using the GCTA-REML method and carried out a genome-wide association study of individual psychological distress symptoms showing significant heritability. RESULTS: We found three psychological distress items showing significant heritability: subjective well-being (9%), fatigue and appetite (11%), and enjoying daily life (8%). Additionally, we found genome-wide significant associations of rs6735649 located between STEAP3 and C1QL2 on chromosome 2 with subjective well-being (P = 1.32 × 10-8, odds ratio [OR] = 1.18, 95% confidence interval [CI]: 1.12-1.25) and rs35543418 located between SYT16 and KCNH5 on chromosome 14 with enjoying daily life (P = 1.33 × 10-8, OR = 1.59, 95% CI: 1.35-1.86). LIMITATIONS: The lack of replication in independent cohorts and longitudinal assessment of distress may limit generalizability. CONCLUSIONS: Our results indicate that distress symptoms are partly heritable. Further analysis in larger cohorts investigating gene-environment interactions is required to identify genetic variants that explain the proportion of variation in distress.
BACKGROUND: Psychological distress symptoms are associated with an increased risk of psychiatric disorders and medical illness. Although psychological distress is influenced by environmental factors, such as socioeconomic status, lifetime events, or interpersonal relationships, substantial interindividual variation also exists. However, heritability and genetic determinants of distress are poorly understood. METHODS: In the Korean Genome and Epidemiology Study sample (n = 12,680), we estimated the heritability of individual psychological distress symptoms using the GCTA-REML method and carried out a genome-wide association study of individual psychological distress symptoms showing significant heritability. RESULTS: We found three psychological distress items showing significant heritability: subjective well-being (9%), fatigue and appetite (11%), and enjoying daily life (8%). Additionally, we found genome-wide significant associations of rs6735649 located between STEAP3 and C1QL2 on chromosome 2 with subjective well-being (P = 1.32 × 10-8, odds ratio [OR] = 1.18, 95% confidence interval [CI]: 1.12-1.25) and rs35543418 located between SYT16 and KCNH5 on chromosome 14 with enjoying daily life (P = 1.33 × 10-8, OR = 1.59, 95% CI: 1.35-1.86). LIMITATIONS: The lack of replication in independent cohorts and longitudinal assessment of distress may limit generalizability. CONCLUSIONS: Our results indicate that distress symptoms are partly heritable. Further analysis in larger cohorts investigating gene-environment interactions is required to identify genetic variants that explain the proportion of variation in distress.
Authors: Eun Ju Baek; Hae Un Jung; Tae-Woong Ha; Dong Jun Kim; Ji Eun Lim; Han Kyul Kim; Ji-One Kang; Bermseok Oh Journal: Front Genet Date: 2022-03-30 Impact factor: 4.599
Authors: Malek Ghandour; Jolin B Yamin; Judith E Arnetz; Mark A Lumley; Paul M Stemmer; Paul Burghardt; Hikmet Jamil; Bengt B Arnetz Journal: Cureus Date: 2022-08-21