Literature DB >> 31001737

Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases.

Alexey M Petrov1, Irina A Pikuleva2.   

Abstract

Cholesterol 24-hydroxylation is the major mechanism for cholesterol removal from the brain and the reaction catalyzed by cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme. This review describes CYP46A1 in the context of cholesterol homeostasis in the brain and summarizes available experimental data on CYP46A1 association with different neurologic diseases, including the mechanisms by which changes in the CYP46A1 activity in the brain could be beneficial for these diseases. The modulation of CYP46A1 activity by genetic and pharmacologic means is also presented along with a brief synopsis of the two clinical trials that evaluate CYP46A1 as a therapeutic target for Alzheimer's disease as well as Dravet and Lennox-Gastaut syndromes.

Entities:  

Keywords:  24-Hydroxycholesterol; CYP46A1; Cholesterol; Cholesterol turnover; Efavirenz; Neurodegeneration

Mesh：

Substances：

Year:  2019        PMID： 31001737      PMCID： PMC6694357          DOI： 10.1007/s13311-019-00731-6

Source DB:  PubMed          Journal:  Neurotherapeutics        ISSN： 1878-7479            Impact factor:   7.620


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