Literature DB >> 3099819

Variations in exposure to mitomycin C in an in vitro colony-forming assay.

P H Slee, E A de Bruijn, P Leeflang, P J Kuppen, L van den Berg, A T van Oosterom.   

Abstract

The effect of mitomycin C on two human ovarian cancer cell lines was measured during several exposure times and concentrations using the Human Tumour Colony-forming Assay (HTCA). Changes in exposure time and concentration resulted in considerable differences in tumour cell survival. It is concluded that several exposure times and concentrations are necessary for in vitro sensitivity testing. We suggest alternative criteria derived from pharmacokinetic data in patients instead of one-tenth of the peak plasma level which is the usual practice.

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Year:  1986        PMID： 3099819      PMCID： PMC2001588          DOI： 10.1038/bjc.1986.266

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  18 in total

1.  Comparison of in vitro methods to determine drug-induced cell lethality.

Authors:  P R Roper; B Drewinko
Journal:  Cancer Res       Date:  1976-07       Impact factor: 12.701

2.  The human tumour colony-forming assay using fresh specimens.

Authors:  P H Slee; A T Van Oosterom; L Van den Berg; E A De Bruijn
Journal:  Neth J Med       Date:  1986       Impact factor: 1.422

3.  Pharmacologic studies of anticancer drugs with the human tumor stem cell assay.

Authors:  D S Alberts; S E Salmon; H S Chen; T E Moon; L Young; E A Surwit
Journal:  Cancer Chemother Pharmacol       Date:  1981       Impact factor: 3.333

4.  The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time.

Authors:  S Riegelman; P Collier
Journal:  J Pharmacokinet Biopharm       Date:  1980-10

5.  Time-dose relationships for 5-fluorouracil cytotoxicity against human epithelial cancer cells in vitro.

Authors:  P M Calabro-Jones; J E Byfield; J F Ward; T R Sharp
Journal:  Cancer Res       Date:  1982-11       Impact factor: 12.701

6.  Cytotoxic thresholds of vincristine in a murine and a human leukemia cell line in vitro.

Authors:  D V Jackson; R A Bender
Journal:  Cancer Res       Date:  1979-11       Impact factor: 12.701

7.  Time- and concentration-dependent inhibition of the clonogenic growth of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced murine bladder tumor cell lines by cis-diamminedichloroplatinum(II).

Authors:  H B Niell; C A Wood; D D Mickey; M S Soloway
Journal:  Cancer Res       Date:  1982-03       Impact factor: 12.701

8.  Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs.

Authors:  S E Salmon; A W Hamburger; B Soehnlen; B G Durie; D S Alberts; T E Moon
Journal:  N Engl J Med       Date:  1978-06-15       Impact factor: 91.245

9.  Association between human tumor colony-forming assay results and response of an individual patient's tumor to chemotherapy.

Authors:  D D Von Hoff; J Casper; E Bradley; J Sandbach; D Jones; R Makuch
Journal:  Am J Med       Date:  1981-05       Impact factor: 4.965

10.  In vitro chemosensitivity tests on xenografted human melanomas.

Authors:  A E Bateman; P J Selby; G G Steel; G D Towse
Journal:  Br J Cancer       Date:  1980-02       Impact factor: 7.640
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  4 in total

1.  High mitomycin C concentration in tumour tissue can be achieved by isolated liver perfusion in rats.

Authors:  A Marinelli; D H Pons; J A Vreeken; S K Nagesser; P J Kuppen; U R Tjaden; C J van de Velde
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

2.  Pharmacokinetics of UGN-101, a mitomycin-containing reverse thermal gel instilled via retrograde catheter for the treatment of low-grade upper tract urothelial carcinoma.

Authors:  Ahmad Shabsigh; Nir Kleinmann; Angela B Smith; Douglas Scherr; Elyse Seltzer; Mark Schoenberg; Seth P Lerner
Journal:  Cancer Chemother Pharmacol       Date:  2021-03-07       Impact factor: 3.333

3.  Effects of chemotherapeutic agents on alpha-fetoprotein secretion and growth of human hepatoma cell lines in vitro.

Authors:  A Muraoka; T Tokiwa; J Sato
Journal:  Br J Cancer       Date:  1989-04       Impact factor: 7.640

4.  A comparative study of isolated liver perfusion versus hepatic artery infusion with mitomycin C in rats.

Authors:  A Marinelli; C J van de Velde; P J Kuppen; H C Franken; J H Souverijn; A M Eggermont
Journal:  Br J Cancer       Date:  1990-12       Impact factor: 7.640
  4 in total

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