Literature DB >> 2469455

Effects of chemotherapeutic agents on alpha-fetoprotein secretion and growth of human hepatoma cell lines in vitro.

A Muraoka1, T Tokiwa, J Sato.   

Abstract

The effects of various chemotherapeutic agents on alpha-fetoprotein (AFP) secretion and growth of human hepatocellular carcinoma and hepatoblastoma cell lines were investigated in vitro. It was found that there was a high correlation between hepatoma cell number and AFP secretion after treatment and that the amount of AFP secreted per cell per 72 h was not affected with therapeutically achievable concentrations. These results suggest that serum AFP level in patients with hepatomas does not correlate with the size of whole tumour but with that of viable tumour mass, and that AFP-secreting capacity of tumour cells in the mass is kept unchanged after chemotherapy.

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Year:  1989        PMID： 2469455      PMCID： PMC2247148          DOI： 10.1038/bjc.1989.115

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  18 in total

1.  Effect of surgical and chemotherapeutic treatment on alpha-fetoprotein levels in patients with hepatocellular carcinoma.

Authors:  K R McIntire; C L Vogel; A Primack; T A Waldmann; S K Kyalwazi
Journal:  Cancer       Date:  1976-02       Impact factor: 6.860

2.  Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma.

Authors:  I Doi
Journal:  Gan       Date:  1976-02

3.  Human tumor colony assay and chemosensitivity testing.

Authors:  S E Salmon
Journal:  Cancer Treat Rep       Date:  1984-01

4.  Growth of human hepatoma cells lines with differentiated functions in chemically defined medium.

Authors:  H Nakabayashi; K Taketa; K Miyano; T Yamane; J Sato
Journal:  Cancer Res       Date:  1982-09       Impact factor: 12.701

5.  The interpretation of marker protein assays: a critical appraisal in clinical studies and a xenograft model.

Authors:  D Raghavan; J Gibbs; R Nogueira Costa; J Kohn; A H Orr; A Barrett; M J Peckham
Journal:  Br J Cancer Suppl       Date:  1980-04

6.  Serum alpha-fetoprotein estimations and doubling time in hepatocellular carcinoma: influence of therapy and possible value in early detection.

Authors:  P J Johnson; R Williams
Journal:  J Natl Cancer Inst       Date:  1980-06       Impact factor: 13.506

7.  Alpha feta (alpha FP) monitoring of response to adriamycin in hepatoblastoma.

Authors:  J Pritchard; A da Cunha; M A Cornbleet; C J Carter
Journal:  J Pediatr Surg       Date:  1982-08       Impact factor: 2.545

8.  Growth characteristics of alpha-foetoprotein-secreting human hepatocellular carcinoma in athymic (nude) mice.

Authors:  M F Bassendine; N A Wright; H C Thomas; S Sherlock
Journal:  Clin Sci (Lond)       Date:  1983-06       Impact factor: 6.124

9.  Association between human tumor colony-forming assay results and response of an individual patient's tumor to chemotherapy.

Authors:  D D Von Hoff; J Casper; E Bradley; J Sandbach; D Jones; R Makuch
Journal:  Am J Med       Date:  1981-05       Impact factor: 4.965

10.  Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717.

Authors:  N J Curtin; A L Harris; O F James; M F Bassendine
Journal:  Br J Cancer       Date:  1986-03       Impact factor: 7.640
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  2 in total

1.  Butyrate decreases AFP and increases albumin in combination with laminin in a human hepatoma cell line.

Authors:  T Tokiwa; A Endo; J Sato
Journal:  In Vitro Cell Dev Biol       Date:  1990-03

2.  Rapid decrease of serum alpha-fetoprotein and tumor volume predicts outcome in children with hepatoblastoma treated with neoadjuvant chemotherapy.

Authors:  Rosa Nguyen; M Beth McCarville; April Sykes; Shenghua Mao; Jianrong Wu; Max R Langham; Wayne L Furman
Journal:  Int J Clin Oncol       Date:  2018-05-09       Impact factor: 3.402
  2 in total

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