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Literature DB >> 3099793

Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease.

E Montejo de Garcini, L Serrano, J Avila.

Abstract

Microtubule associated protein tau factor self-assembles into filamentous structures resembling the paired helical filaments found in Alzheimer disease. Tau polymerization requires of a previous modification; conversion of glutamine into glutamic acid by deamination.

Entities: Chemical Disease Gene

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Substances：

Year: 1986 PMID： 3099793 DOI： 10.1016/s0006-291x(86)80242-x

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

34 in total

1. Tau dephosphorylation at tau-1 site correlates with its association to cell membrane.

Authors: M Arrasate; M Pérez; J Avila
Journal: Neurochem Res Date: 2000-01 Impact factor: 3.996

2. Role of glycosaminoglycans in determining the helicity of paired helical filaments.

Authors: M Arrasate; M Pérez; J M Valpuesta; J Avila
Journal: Am J Pathol Date: 1997-10 Impact factor: 4.307

3. A Critical Assessment of Research on Neurotransmitters in Alzheimer's Disease.

Authors: P Hemachandra Reddy
Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472

Review 4. Cellular factors modulating the mechanism of tau protein aggregation.

Authors: Sarah N Fontaine; Jonathan J Sabbagh; Jeremy Baker; Carlos R Martinez-Licha; April Darling; Chad A Dickey
Journal: Cell Mol Life Sci Date: 2015-02-11 Impact factor: 9.261

5. Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein.

Authors: F Coria; E M Castaño; B Frangione
Journal: Am J Pathol Date: 1987-12 Impact factor: 4.307

Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease.

1. Tau dephosphorylation at tau-1 site correlates with its association to cell membrane.

2. Role of glycosaminoglycans in determining the helicity of paired helical filaments.

3. A Critical Assessment of Research on Neurotransmitters in Alzheimer's Disease.

Review 4. Cellular factors modulating the mechanism of tau protein aggregation.

5. Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein.

6. The role of tau phosphorylation in transfected COS-1 cells.

7. PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners.

8. Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.

Review 9. Tau function and dysfunction in neurons: its role in neurodegenerative disorders.

10. Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.