Literature DB >> 30997832

IL-25 contributes to lung fibrosis by directly acting on alveolar epithelial cells and fibroblasts.

Xuefeng Xu1, Sa Luo2,3, Biyun Li2,3, Huaping Dai2,3, Jinglan Zhang1.   

Abstract

IMPACT STATEMENT: Our work focused on alveolar epithelial cells (AECs)-derived type-2 cytokine (interleukin [IL]-25) in the pathogenesis of idiopathic pulmonary fibrosis (IPF). We showed that IL-25 and IL-17BR (IL-25's receptor) is upregulated in lung tissues (especially in AECs and lung fibroblasts) of IPF patients and contributes to lung fibrosis by directly activating lung fibroblasts and modulating epithelial-mesenchymal transition (EMT) of AECs. We suggest that IL-25 may be one of the master switches hidden in the milieu of abnormal epithelial-mesenchymal crosstalk. Treatment targeting IL-25 may be the potential and novel method for IPF patients.

Entities:  

Keywords:  Alveolar epithelial cells; fibroblasts; interleukin-25; lung fibrosis; murine model

Mesh：

Substances：

Year:  2019        PMID： 30997832      PMCID： PMC6567590          DOI： 10.1177/1535370219843827

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  31 in total

1.  Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia.

Authors:  D S Southam; M Dolovich; P M O'Byrne; M D Inman
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2002-04       Impact factor: 5.464

2.  Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastat.

Authors:  M Corbel; S Caulet-Maugendre; N Germain; S Molet; V Lagente; E Boichot
Journal:  J Pathol       Date:  2001-04       Impact factor: 7.996

Review 3.  Fibrotic disease and the T(H)1/T(H)2 paradigm.

Authors:  Thomas A Wynn
Journal:  Nat Rev Immunol       Date:  2004-08       Impact factor: 53.106

Review 4.  Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers.

Authors:  Moisés Selman; Annie Pardo
Journal:  Proc Am Thorac Soc       Date:  2006-06

5.  Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats.

Authors:  Kenji Adachi; Keiji Mizoguchi; Shinya Kawarada; Akio Miyoshi; Masami Suzuki; Shuichi Chiba; Toshiaki Deki
Journal:  J Toxicol Sci       Date:  2010-08       Impact factor: 2.196

6.  Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis.

Authors:  Amber L Degryse; Harikrishna Tanjore; Xiaochuan C Xu; Vasiliy V Polosukhin; Brittany R Jones; Frank B McMahon; Linda A Gleaves; Timothy S Blackwell; William E Lawson
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2010-06-18       Impact factor: 5.464

7.  Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF.

Authors:  L H Pan; K Yamauchi; M Uzuki; T Nakanishi; M Takigawa; H Inoue; T Sawai
Journal:  Eur Respir J       Date:  2001-06       Impact factor: 16.671

8.  Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis.

Authors:  Craig E Daniels; Mark C Wilkes; Maryanne Edens; Ted J Kottom; Stephen J Murphy; Andrew H Limper; Edward B Leof
Journal:  J Clin Invest       Date:  2004-11       Impact factor: 14.808

9.  IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts.

Authors:  Séverine Létuvé; Stéphane Lajoie-Kadoch; Séverine Audusseau; Marc E Rothenberg; Pierre-Olivier Fiset; Mara S Ludwig; Qutayba Hamid
Journal:  J Allergy Clin Immunol       Date:  2006-02-08       Impact factor: 10.793

10.  Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma.

Authors:  Sarah J Ballantyne; Jillian L Barlow; Helen E Jolin; Puneeta Nath; Alison S Williams; Kian Fan Chung; Graham Sturton; See Heng Wong; Andrew N J McKenzie
Journal:  J Allergy Clin Immunol       Date:  2007-09-24       Impact factor: 10.793
View more
  6 in total

Review 1.  IL-25/IL-33/TSLP contributes to idiopathic pulmonary fibrosis: Do alveolar epithelial cells and (myo)fibroblasts matter?

Authors:  Xuefeng Xu; Jinglan Zhang; Huaping Dai
Journal:  Exp Biol Med (Maywood)       Date:  2020-04-04

Review 2.  Role of interleukins in the pathogenesis of pulmonary fibrosis.

Authors:  Yi Xin She; Qing Yang Yu; Xiao Xiao Tang
Journal:  Cell Death Discov       Date:  2021-03-15

Review 3.  COVID-19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts.

Authors:  Alison E John; Chitra Joseph; Gisli Jenkins; Amanda L Tatler
Journal:  Immunol Rev       Date:  2021-05-24       Impact factor: 10.983

4.  Interleukin-25-Mediated-IL-17RB Upregulation Promotes Cutaneous Wound Healing in Diabetic Mice by Improving Endothelial Cell Functions.

Authors:  Fang Zhang; Ye Liu; Shiqi Wang; Xin Yan; Yue Lin; Deyan Chen; Qian Tan; Zhiwei Wu
Journal:  Front Immunol       Date:  2022-01-20       Impact factor: 7.561

Review 5.  Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis.

Authors:  Yun-Juan Nie; Shuo-Hua Wu; Ying-Hua Xuan; Gen Yan
Journal:  Mil Med Res       Date:  2022-05-12

6.  Epithelial Alarmins in Serum and Exhaled Breath in Patients with Idiopathic Pulmonary Fibrosis: A Prospective One-Year Follow-Up Cohort Study.

Authors:  Sebastian Majewski; Karolina Szewczyk; Adam J Białas; Joanna Miłkowska-Dymanowska; Paweł Górski; Wojciech J Piotrowski
Journal:  J Clin Med       Date:  2019-10-02       Impact factor: 4.241
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.