Literature DB >> 3099297

Induced mRNA stability in Bacillus subtilis.

D H Bechhofer, D Dubnau.   

Abstract

We have investigated the induced stability of mRNA encoded by the ermC gene in Bacillus subtilis. Induction of ermC gene expression by erythromycin is known to occur at the translational level. We show that this induction is accompanied by an increase in ermC mRNA half-life from about 2 min to about 40 min. Induced stabilization of ermC mRNA occurs independently of induced translation. The regulatory sequences required for stability are promoter-proximal and can confer induced stability on large mRNAs having diverse 3' ends. Translation of the ermC leader peptide and ribosome-stalling in the leader peptide sequence are necessary for induced stabilization.

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Year:  1987        PMID： 3099297      PMCID： PMC304236          DOI： 10.1073/pnas.84.2.498

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  36 in total

1.  Synthesis of Specific, Stabilized Messenger RNA When Translocation Is Blocked in ESCHERICHIA COLI.

Authors:  E Craig
Journal:  Genetics       Date:  1972-02       Impact factor: 4.562

2.  Polynucleotide phosphorylase and ribonuclease II are required for cell viability and mRNA turnover in Escherichia coli K-12.

Authors:  W P Donovan; S R Kushner
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

3.  Translation and mRNA decay.

Authors:  E Schneider; M Blundell; D Kennell
Journal:  Mol Gen Genet       Date:  1978-04-06

4.  Map location and nucleotide sequence of korA, a key regulatory gene of promiscuous plasmid RK2.

Authors:  D H Bechhofer; D H Figurski
Journal:  Nucleic Acids Res       Date:  1983-11-11       Impact factor: 16.971

5.  Evidence that the 5' end of lac mRNA starts to decay as soon as it is synthesized.

Authors:  V J Cannistraro; D Kennell
Journal:  J Bacteriol       Date:  1985-02       Impact factor: 3.490

6.  Erythromycin-inducible resistance in Staphylococcus aureus: requirements for induction.

Authors:  B Weisblum; C Siddhikol; C J Lai; V Demohn
Journal:  J Bacteriol       Date:  1971-06       Impact factor: 3.490

7.  Replication and incompatibility properties of plasmid pE194 in Bacillus subtilis.

Authors:  T J Gryczan; J Hahn; S Contente; D Dubnau
Journal:  J Bacteriol       Date:  1982-11       Impact factor: 3.490

8.  Characterization of a plasmid-specified ribosome methylase associated with macrolide resistance.

Authors:  A G Shivakumar; D Dubnau
Journal:  Nucleic Acids Res       Date:  1981-06-11       Impact factor: 16.971

9.  Posttranscriptional regulation of an erythromycin resistance protein specified by plasmic pE194.

Authors:  A G Shivakumar; J Hahn; G Grandi; Y Kozlov; D Dubnau
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

10.  Induction of macrolide-lincosamide-streptogramin B resistance requires ribosomes able to bind inducer.

Authors:  T J Gryczan; M Israeli-Reches; D Dubnau
Journal:  Mol Gen Genet       Date:  1984
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  56 in total

1.  Regulation of the macrolide-lincosamide-streptogramin B resistance gene ermD.

Authors:  K K Hue; D H Bechhofer
Journal:  J Bacteriol       Date:  1992-09       Impact factor: 3.490

2.  Identification of cis-acting sequences required for translational autoregulation of the ermC methylase.

Authors:  F Breidt; D Dubnau
Journal:  J Bacteriol       Date:  1990-07       Impact factor: 3.490

3.  mRNA stabilizing signals encoded in the genome of the bacteriophage phi x174.

Authors:  M N Hayashi; R Yaghmai; M McConnell; M Hayashi
Journal:  Mol Gen Genet       Date:  1989-04

4.  The ompA 5' untranslated RNA segment functions in Escherichia coli as a growth-rate-regulated mRNA stabilizer whose activity is unrelated to translational efficiency.

Authors:  S A Emory; J G Belasco
Journal:  J Bacteriol       Date:  1990-08       Impact factor: 3.490

Review 5.  Modes and modulations of antibiotic resistance gene expression.

Authors:  Florence Depardieu; Isabelle Podglajen; Roland Leclercq; Ekkehard Collatz; Patrice Courvalin
Journal:  Clin Microbiol Rev       Date:  2007-01       Impact factor: 26.132

6.  Differential stability of mRNA species of Alcaligenes eutrophus soluble and particulate hydrogenases.

Authors:  U Oelmüller; H G Schlegel; C G Friedrich
Journal:  J Bacteriol       Date:  1990-12       Impact factor: 3.490

7.  Changes in the stability of specific mRNA species in response to growth stage in Bacillus subtilis.

Authors:  O Resnekov; L Rutberg; A von Gabain
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

8.  Effect of ermC leader region mutations on induced mRNA stability.

Authors:  K K Hue; D H Bechhofer
Journal:  J Bacteriol       Date:  1991-06       Impact factor: 3.490

9.  Decay of ompA mRNA and processing of 9S RNA are immediately affected by shifts in growth rate, but in opposite manners.

Authors:  D Georgellis; S Arvidson; A von Gabain
Journal:  J Bacteriol       Date:  1992-08       Impact factor: 3.490

10.  Initiation of RNA decay in Escherichia coli by 5' pyrophosphate removal.

Authors:  Helena Celesnik; Atilio Deana; Joel G Belasco
Journal:  Mol Cell       Date:  2007-07-06       Impact factor: 17.970
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