| Literature DB >> 30988471 |
Xiao Lin1, Yue Liu2, Aobing Bai3, Huanhuan Cai3, Yanjie Bai4, Wei Jiang3, Huilin Yang1,5, Xinhong Wang3, Lei Yang6,7,8, Ning Sun9,10,11, Huajian Gao12.
Abstract
Acellular epicardial patches that treat myocardial infarction by increasing the mechanical integrity of damaged left ventricular tissues exhibit widely scattered therapeutic efficacy. Here, we introduce a viscoelastic adhesive patch, made of an ionically crosslinked transparent hydrogel, that accommodates the cyclic deformation of the myocardium and outperforms most existing acellular epicardial patches in reversing left ventricular remodelling and restoring heart function after both acute and subacute myocardial infarction in rats. The superior performance of the patch results from its relatively low dynamic modulus, designed at the so-called 'gel point' via finite-element simulations of left ventricular remodelling so as to balance the fluid and solid properties of the material.Entities:
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Year: 2019 PMID： 30988471 DOI： 10.1038/s41551-019-0380-9
Source DB: PubMed Journal: Nat Biomed Eng ISSN： 2157-846X Impact factor: 25.671