Xavier León1, Jacinto García2, Montserrat López2, Camilo Rodriguez2, Alfons Gutierrez2, Miquel Quer2. 1. Servicio de Otorrinolaringología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, España. Electronic address: xleon@santpau.cat. 2. Servicio de Otorrinolaringología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España.
Abstract
OBJECTIVE: To analyse the incidence of appearance of second and successive neoplasms in a cohort of head and neck squamous carcinoma patients. MATERIAL AND METHODS: We conducted a retrospective study with 4,458 patients with an index tumour located in the head and neck diagnosed during the 1985-2016 period. We evaluated the incidence of appearance of second neoplasms and successive neoplasms over a period of 30 years. RESULTS: During the follow-up, 1,203 patients (27.0%) had a second neoplasm, 242 patients (5.4%) a third neoplasm, 58 patients (1.3%) a fourth neoplasm, and 8 patients (0.2%) 5 or more successive neoplasms. The incidence of appearance of second neoplasms was 3.5% per year, remaining relatively constant throughout the follow-up period. The patients with a second neoplasm had a higher risk of appearance of a third neoplasm, and those with a third neoplasm had a higher risk of a fourth. Seventy-eight percent of the second neoplasms, 88% of the third neoplasms, and 89.6% of the fourth neoplasms appeared in locations epidemiologically related to tobacco and alcohol use. CONCLUSIONS: Second neoplasms after a head and neck index tumour appeared at a constant rate of 3.5% per year throughout the entire follow-up period.
OBJECTIVE: To analyse the incidence of appearance of second and successive neoplasms in a cohort of head and neck squamous carcinomapatients. MATERIAL AND METHODS: We conducted a retrospective study with 4,458 patients with an index tumour located in the head and neck diagnosed during the 1985-2016 period. We evaluated the incidence of appearance of second neoplasms and successive neoplasms over a period of 30 years. RESULTS: During the follow-up, 1,203 patients (27.0%) had a second neoplasm, 242 patients (5.4%) a third neoplasm, 58 patients (1.3%) a fourth neoplasm, and 8 patients (0.2%) 5 or more successive neoplasms. The incidence of appearance of second neoplasms was 3.5% per year, remaining relatively constant throughout the follow-up period. The patients with a second neoplasm had a higher risk of appearance of a third neoplasm, and those with a third neoplasm had a higher risk of a fourth. Seventy-eight percent of the second neoplasms, 88% of the third neoplasms, and 89.6% of the fourth neoplasms appeared in locations epidemiologically related to tobacco and alcohol use. CONCLUSIONS: Second neoplasms after a head and neck index tumour appeared at a constant rate of 3.5% per year throughout the entire follow-up period.
Keywords:
Carcinoma escamoso de cabeza y cuello; Index tumour; Neoplasias sucesivas; Second neoplasms; Segundas neoplasias; Squamous carcinoma of head and neck; Successive neoplasms; Tumor índice
Authors: John M Hoyle; Tanya A Correya; Kelly Kenzik; Liton Francisco; Sharon A Spencer; Christopher D Willey; James A Bonner; James W Snider; Drexell Hunter Boggs; William R Carroll; Smita Bhatia; Andrew M McDonald Journal: Head Neck Date: 2022-01-25 Impact factor: 3.147