| Literature DB >> 30982430 |
Catalina Pineda Molina1,2, George S Hussey1,3, Jonas Eriksson1,3, Michael A Shulock1,2, Laura L Cárdenas Bonilla1, Ross M Giglio1,2, Riddhi M Gandhi1,2, Brian M Sicari1,3, Derek Wang1, Ricardo Londono1, Denver M Faulk1,2, Neill J Turner1,3, Stephen F Badylak1,2,3.
Abstract
IMPACT STATEMENT: This study evaluated the biological activity of hydroxylated derivatives of butyrate as inductors of antimicrobial peptides (AMPs) in murine bone marrow-derived macrophages in vitro. A differential modulation of AMP expression by the hydroxylated derivatives of butyrate is shown. The ability of sodium 4-hydroxybutyrate to upregulate AMP expression through a histone deacetylase inhibitory-independent mechanism, and to promote increased resistance to bacterial contamination in vivo are also shown. The findings provide an alternative for prevention of bacterial contamination of implanted biomaterials. Functionalization of biomaterials with hydroxylated derivatives of butyrate can enhance the endogenous antimicrobial activity of the immune system through increased production of AMPs by host cells, thus providing protection against bacterial contamination.Entities:
Keywords: 2-hydroxybutyrate; 3-hydroxybutyrate; 4-hydroxybutyrate; antimicrobial peptides; histone deacetylase inhibition; short chain fatty acids; sodium butyrate
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Year: 2019 PMID： 30982430 DOI： 10.1089/ten.TEA.2018.0377
Source DB: PubMed Journal: Tissue Eng Part A ISSN： 1937-3341 Impact factor: 3.845