| Literature DB >> 30981763 |
Liang Yang1, Shuo Yang1, Xinyu Li1, Bowen Li1, Yan Li1, Xiaodong Zhang1, Yingbo Ma1, Xueqiang Peng1, Hongyuan Jin1, Qing Fan1, Shibo Wei1, Jingang Liu1, Hangyu Li2.
Abstract
Tumor models have created new avenues for personalized medicine and drug development. A new culture model derived from a three-dimensional system, the tumor organoid, is gradually being used in many fields. An organoid can simulate the physiological structure and function of tissue in situ and maintain the characteristics of tumor cells in vivo, overcoming the disadvantages of traditional experimental tumor models. Organoids can mimic pathological features of tumors and maintain genetic stability, making them suitable for both molecular mechanism studies and pharmacological experiments of clinical transformation. In addition, the application of tumor organoids combined with other technologies, such as liquid biopsy technology, microraft array (MRA), and high-content screening (HCS), for the development of personalized diagnosis and cancer treatment has a promising future. In this review, we introduce the evolution of organoids and discuss their specific application and advantages. We also summarize the characteristics of several tumor organoids culture systems.Entities:
Keywords: 3D culture; Cancer models; Drug discovery; Personalized medicine; Tumor organoids
Year: 2019 PMID： 30981763 DOI： 10.1016/j.canlet.2019.04.005
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679