Literature DB >> 30981579

Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.

Markos-Orestis Georgiadis1, Violeta Kourbeli1, Vaya Ioannidou1, Evangelos Karakitsios1, Ioannis Papanastasiou2, Andrew Tsotinis1, Dimitri Komiotis3, Anthony Vocat4, Stewart T Cole5, Martin C Taylor6, John M Kelly6.   

Abstract

In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Aminoalkane side chain; Antimycobacterial activity; Diphenoxyadamantane; Substituted piperazine; Trypanocidal activity

Year:  2019        PMID： 30981579     DOI： 10.1016/j.bmcl.2019.04.010

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  1 in total

1.  Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei.

Authors:  Markos-Orestis Georgiadis; Violeta Kourbeli; Ioannis P Papanastasiou; Andrew Tsotinis; Martin C Taylor; John M Kelly
Journal:  RSC Med Chem       Date:  2019-12-19
  1 in total

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