Roni Meidan1,2, Omer Bar-Yosef1,3, Itay Ashkenazi1, Orr Yahal1,3, Michal Berkenstadt1,4, Chen Hoffman1,5, Abraham Tsur1,2,6, Reuven Achiron1,2, Eldad Katorza1,2. 1. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 2. Antenatal Diagnostic Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel. 3. Pediatric Neurology Unit, Sheba Medical Center, Tel Hashomer, Israel. 4. Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel. 5. Neuroradiology Unit, Department of Diagnostic Radiology, Sheba Medical Center, Tel Hashomer, Israel. 6. Department of Obstetrics & Gynecology, Stanford University School of Medicine, CA, USA.
Abstract
OBJECTIVE: Data regarding the neurodevelopmental outcome of fetal short corpus callosum (CC) diagnosed according to standard reference charts is scarce. The purpose of this study was to assess whether the finding is related to neurodevelopmental delay, and to examine reclassification to normal fetal CC length using CC length/EFW ratio. METHOD: Historical prospective cohort study including pregnant women who were referred for fetal neurosonogram due to abnormal CC. Short CC was defined below the 5th percentile according to reference charts. Twenty cases were included in the study group and compared with a control group of 59 normal cases. The patients in the study group were divided into two groups according to CC length/EFW ratio. Children's neurodevelopment was assessed using the Vineland Adaptive Behavior Scale (VABS). RESULTS: VABS scores were within normal range in 90% of the cases. There was no significant statistical difference between the study group and the control group. In addition, there was no statistically significant difference between fetuses reclassified as normal callosal length according to CC length/EFW ratio in comparison to the control group. CONCLUSION: The neurodevelopmental outcome of fetuses with diagnosed short CC did not differ from the neurodevelopment of normal fetuses in the control group.
OBJECTIVE: Data regarding the neurodevelopmental outcome of fetal short corpus callosum (CC) diagnosed according to standard reference charts is scarce. The purpose of this study was to assess whether the finding is related to neurodevelopmental delay, and to examine reclassification to normal fetal CC length using CC length/EFW ratio. METHOD: Historical prospective cohort study including pregnant women who were referred for fetal neurosonogram due to abnormal CC. Short CC was defined below the 5th percentile according to reference charts. Twenty cases were included in the study group and compared with a control group of 59 normal cases. The patients in the study group were divided into two groups according to CC length/EFW ratio. Children's neurodevelopment was assessed using the Vineland Adaptive Behavior Scale (VABS). RESULTS:VABS scores were within normal range in 90% of the cases. There was no significant statistical difference between the study group and the control group. In addition, there was no statistically significant difference between fetuses reclassified as normal callosal length according to CC length/EFW ratio in comparison to the control group. CONCLUSION: The neurodevelopmental outcome of fetuses with diagnosed short CC did not differ from the neurodevelopment of normal fetuses in the control group.
Authors: A-E Millischer; D Grevent; P Sonigo; N Bahi-Buisson; I Desguerre; H Mahallati; J-P Bault; T Quibel; S Couderc; M-L Moutard; E Julien; V Dangouloff; B Bessieres; V Malan; T Attie; L-J Salomon; N Boddaert Journal: AJNR Am J Neuroradiol Date: 2021-12-23 Impact factor: 3.825