Daniel R Newman1, Mohammad M Rahman1,2, Antoine Brantley2, Thomas A Peterman1. 1. Division of sexually transmitted diseases (STD) Prevention, National Center for Human Immunodeficiency Virus (HIV), Hepatitis, STD, and tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia. 2. STD/HIV Program, Louisiana Department of Health, New Orleans.
Abstract
BACKGROUND: Human immunodeficiency virus (HIV) prevention interventions for prevention interventions for women include screening, partner notification, promoting condoms, and preexposure prophylaxis (PrEP). Women's risk of acquiring HIV can help guide recommendations. METHODS: We used data from Louisiana's sexually transmitted infection (STI) and HIV registries to study 13- to 59-year-old women following first diagnosis of syphilis, gonorrhea, or chlamydia during 2000-2015. We measured HIV rates reported subsequent to STI (through 2016). Rates for women without STI were estimated by subtracting women with STI from reported cases and from Census estimates for the population. PrEP cost was estimated as $11 000 per year, and effectiveness estimated as 100%. RESULTS: STIs were syphilis (6574), gonorrhea (64 995), or chlamydia (140 034). These 211 603 women had 1 865 488 person-years of follow-up and 969 HIV diagnoses. Women with no STI had 5186 HIV diagnoses over 24 359 397 person-years. HIV rates diagnosis (per 100 000 person-years) were higher for women after syphilis (177.3), gonorrhea (73.2), or chlamydia (35.4) compared to women with no STI (22.4). Providing PrEP to all women diagnosed with syphilis or gonorrhea would cost $7 371 111 000 and could have prevented 546 HIV diagnoses. Limiting PrEP to 1 year after syphilis or gonorrhea diagnosis would cost $963 847 334, but only 143 HIV diagnoses were within 2 years after a syphilis or gonorrhea diagnosis. CONCLUSIONS: Rates of HIV diagnosis were high after women had STI, but not high enough to make PrEP cost-effective for them. Most women diagnosed with HIV did not have previously reported STI. Published by Oxford University Press for the Infectious Diseases Society of America 2019.
BACKGROUND:Human immunodeficiency virus (HIV) prevention interventions for prevention interventions for women include screening, partner notification, promoting condoms, and preexposure prophylaxis (PrEP). Women's risk of acquiring HIV can help guide recommendations. METHODS: We used data from Louisiana's sexually transmitted infection (STI) and HIV registries to study 13- to 59-year-old women following first diagnosis of syphilis, gonorrhea, or chlamydia during 2000-2015. We measured HIV rates reported subsequent to STI (through 2016). Rates for women without STI were estimated by subtracting women with STI from reported cases and from Census estimates for the population. PrEP cost was estimated as $11 000 per year, and effectiveness estimated as 100%. RESULTS: STIs were syphilis (6574), gonorrhea (64 995), or chlamydia (140 034). These 211 603 women had 1 865 488 person-years of follow-up and 969 HIV diagnoses. Women with no STI had 5186 HIV diagnoses over 24 359 397 person-years. HIV rates diagnosis (per 100 000 person-years) were higher for women after syphilis (177.3), gonorrhea (73.2), or chlamydia (35.4) compared to women with no STI (22.4). Providing PrEP to all women diagnosed with syphilis or gonorrhea would cost $7 371 111 000 and could have prevented 546 HIV diagnoses. Limiting PrEP to 1 year after syphilis or gonorrhea diagnosis would cost $963 847 334, but only 143 HIV diagnoses were within 2 years after a syphilis or gonorrhea diagnosis. CONCLUSIONS: Rates of HIV diagnosis were high after women had STI, but not high enough to make PrEP cost-effective for them. Most women diagnosed with HIV did not have previously reported STI. Published by Oxford University Press for the Infectious Diseases Society of America 2019.
Authors: Myron S Cohen; Ying Q Chen; Marybeth McCauley; Theresa Gamble; Mina C Hosseinipour; Nagalingeswaran Kumarasamy; James G Hakim; Johnstone Kumwenda; Beatriz Grinsztejn; Jose H S Pilotto; Sheela V Godbole; Sanjay Mehendale; Suwat Chariyalertsak; Breno R Santos; Kenneth H Mayer; Irving F Hoffman; Susan H Eshleman; Estelle Piwowar-Manning; Lei Wang; Joseph Makhema; Lisa A Mills; Guy de Bruyn; Ian Sanne; Joseph Eron; Joel Gallant; Diane Havlir; Susan Swindells; Heather Ribaudo; Vanessa Elharrar; David Burns; Taha E Taha; Karin Nielsen-Saines; David Celentano; Max Essex; Thomas R Fleming Journal: N Engl J Med Date: 2011-07-18 Impact factor: 91.245
Authors: Michael C Thigpen; Poloko M Kebaabetswe; Lynn A Paxton; Dawn K Smith; Charles E Rose; Tebogo M Segolodi; Faith L Henderson; Sonal R Pathak; Fatma A Soud; Kata L Chillag; Rodreck Mutanhaurwa; Lovemore Ian Chirwa; Michael Kasonde; Daniel Abebe; Evans Buliva; Roman J Gvetadze; Sandra Johnson; Thom Sukalac; Vasavi T Thomas; Clyde Hart; Jeffrey A Johnson; C Kevin Malotte; Craig W Hendrix; John T Brooks Journal: N Engl J Med Date: 2012-07-11 Impact factor: 91.245
Authors: G R Seage; S E Holte; D Metzger; B A Koblin; M Gross; C Celum; M Marmor; G Woody; K H Mayer; C Stevens; F N Judson; D McKirnan; A Sheon; S Self; S P Buchbinder Journal: Am J Epidemiol Date: 2001-04-01 Impact factor: 4.897
Authors: Thomas M Rehle; Timothy B Hallett; Olive Shisana; Victoria Pillay-van Wyk; Khangelani Zuma; Henri Carrara; Sean Jooste Journal: PLoS One Date: 2010-06-14 Impact factor: 3.240
Authors: Paul J Feldblum; Mary H Latka; Johann Lombaard; Candice Chetty; Pai-Lien Chen; Connie Sexton; Shelly Fischer Journal: BMJ Open Date: 2012-02-13 Impact factor: 2.692
Authors: Jodie Dionne-Odom; Andrew O Westfall; Julia C Dombrowski; Mari M Kitahata; Heidi M Crane; Michael J Mugavero; Richard D Moore; Maile Karris; Katerina Christopoulos; Elvin Geng; Kenneth H Mayer; Jeanne Marrazzo Journal: Clin Infect Dis Date: 2020-12-03 Impact factor: 9.079
Authors: Heather N Grome; Peter F Rebeiro; Meredith Brantley; Dyanne Herrera-Vasquez; Samantha A Mathieson; April C Pettit Journal: Sex Transm Dis Date: 2021-11-01 Impact factor: 3.868
Authors: Jodie Dionne-Odom; Kimberly Workowski; Charlotte Perlowski; Stephanie N Taylor; Kenneth H Mayer; Candice J McNeil; Matthew M Hamill; Julia C Dombrowski; Teresa A Batteiger; Arlene C Sena; Harold C Wiesenfeld; Lori Newman; Edward W Hook Journal: Sex Transm Dis Date: 2022-01-24 Impact factor: 3.868
Authors: Ikenna Unigwe; Seonkyeong Yang; Hyun Jin Song; Wei-Hsuan Lo-Ciganic; Juan Hincapie-Castillo; Robert L Cook; Haesuk Park Journal: J Clin Med Date: 2021-12-24 Impact factor: 4.241