Zsolt Kovács1, Árpád Kormányos2, Péter Domsik2, Anita Kalapos2, Csaba Lengyel3, Nóra Ambrus2, Zénó Ajtay4,5, Györgyike Á Piros2, Tamás Forster2, Attila Nemes2. 1. Department of Cardiology, Szent Rókus Hospital, Baja, Hungary. 2. 2nd Department of Medicine and Cardiology Centre. 3. 1st Department of Medicine, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary. 4. Vilmos Zsigmondy SPA Hospital, Harkány, Hungary. 5. Heart Institute, Medical School, University of Pécs, Pécs, Hungary.
Abstract
BACKGROUND: The mitral annulus (MA) plays a significant role in promoting left atrial and left ventricular (LV) filling and emptying, which is dependent on LV functional properties. The present study aimed to investigate the relationship between LV strains, quantitative features of longitudinal contractility and MA size and function in healthy subjects. METHODS: The present study comprised 295 healthy adults; 117 subjects were excluded due to inferior image quality (40%). Finally, 178 healthy adults (mean age: 32.0±11.3 years, 92 males). Complete two-dimensional Doppler echocardiography and three-dimensional speckle-tracking echocardiography were performed in all cases. RESULTS: The global and mean segmental left ventricular longitudinal strain (LV-LS) proved to be -16.1%±2.5% and -16.9%±2.4%, respectively. In the present study, LV-LS ≤-13% was considered to be reduced. In ROC analysis, the cut-off value for MA fractional area change (MAFAC) to predict impaired LV-LS was ≤44%, with 67% sensitivity and 69% specificity and ROC area under curve 0.73 (P=0.0005). Significantly increased LV volumes and LV mass and reduced MAFAC could be demonstrated in healthy subjects with global LV-LS ≤-13%. Significantly larger ratio of subjects with global LV-LS ≤-13% had MAFAC ≤44% (31% vs. 67%, P=0.009). Patients with MAFAC ≤44% had significantly reduced global and mean segmental LV-LS. Significantly larger ratio of subjects with MAFAC ≤44% had global LV-LS ≤-13% (4% vs. 16%, P=0.009). CONCLUSIONS: There is a strong relationship between MA and LV longitudinal function. MA fractional area change predicts global LV-LS.
BACKGROUND: The mitral annulus (MA) plays a significant role in promoting left atrial and left ventricular (LV) filling and emptying, which is dependent on LV functional properties. The present study aimed to investigate the relationship between LV strains, quantitative features of longitudinal contractility and MA size and function in healthy subjects. METHODS: The present study comprised 295 healthy adults; 117 subjects were excluded due to inferior image quality (40%). Finally, 178 healthy adults (mean age: 32.0±11.3 years, 92 males). Complete two-dimensional Doppler echocardiography and three-dimensional speckle-tracking echocardiography were performed in all cases. RESULTS: The global and mean segmental left ventricular longitudinal strain (LV-LS) proved to be -16.1%±2.5% and -16.9%±2.4%, respectively. In the present study, LV-LS ≤-13% was considered to be reduced. In ROC analysis, the cut-off value for MA fractional area change (MAFAC) to predict impaired LV-LS was ≤44%, with 67% sensitivity and 69% specificity and ROC area under curve 0.73 (P=0.0005). Significantly increased LV volumes and LV mass and reduced MAFAC could be demonstrated in healthy subjects with global LV-LS ≤-13%. Significantly larger ratio of subjects with global LV-LS ≤-13% had MAFAC ≤44% (31% vs. 67%, P=0.009). Patients with MAFAC ≤44% had significantly reduced global and mean segmental LV-LS. Significantly larger ratio of subjects with MAFAC ≤44% had global LV-LS ≤-13% (4% vs. 16%, P=0.009). CONCLUSIONS: There is a strong relationship between MA and LV longitudinal function. MA fractional area change predicts global LV-LS.
Authors: Attila Nemes; Györgyike Ágnes Piros; Péter Domsik; Anita Kalapos; Csaba Lengyel; Tamás T Várkonyi; Andrea Orosz; Tamás Forster Journal: Quant Imaging Med Surg Date: 2015-12
Authors: Tomasz G Witkowski; James D Thomas; Philippe J M R Debonnaire; Victoria Delgado; Ulas Hoke; See H Ewe; Michel I M Versteegh; Eduard R Holman; Martin J Schalij; Jeroen J Bax; Robert J M Klautz; Nina Ajmone Marsan Journal: Eur Heart J Cardiovasc Imaging Date: 2012-07-29 Impact factor: 6.875
Authors: Zhaolu Wang; Huiyuan Qin; Guilin Chen; Vincent C T Mok; Yan Dai; Yingyuan Cai; Xi Cheng; Yun Qian; Ming Chu; Xiaowei Lu Journal: Quant Imaging Med Surg Date: 2020-03