| Literature DB >> 30975860 |
Francine E Garrett-Bakelman1,2, Manjula Darshi3, Stefan J Green4, Ruben C Gur5, Ling Lin6, Brandon R Macias7, Miles J McKenna8, Cem Meydan1,9, Tejaswini Mishra6, Jad Nasrini5, Brian D Piening6, Lindsay F Rizzardi10, Kumar Sharma3, Jamila H Siamwala11, Lynn Taylor8, Martha Hotz Vitaterna12, Maryam Afkarian13, Ebrahim Afshinnekoo1,9, Sara Ahadi6, Aditya Ambati6, Maneesh Arya7, Daniela Bezdan1,9, Colin M Callahan10, Songjie Chen6, Augustine M K Choi1, George E Chlipala4, Kévin Contrepois6, Marisa Covington14, Brian E Crucian14, Immaculata De Vivo15, David F Dinges5, Douglas J Ebert7, Jason I Feinberg10, Jorge A Gandara1, Kerry A George7, John Goutsias10, George S Grills1, Alan R Hargens11, Martina Heer16, Ryan P Hillary6, Andrew N Hoofnagle17, Vivian Y H Hook11, Garrett Jenkinson10, Peng Jiang12, Ali Keshavarzian18, Steven S Laurie7, Brittany Lee-McMullen6, Sarah B Lumpkins19, Matthew MacKay1, Mark G Maienschein-Cline4, Ari M Melnick1, Tyler M Moore5, Kiichi Nakahira1, Hemal H Patel11, Robert Pietrzyk7, Varsha Rao6, Rintaro Saito11, Denis N Salins6, Jan M Schilling11, Dorothy D Sears11, Caroline K Sheridan1, Michael B Stenger14, Rakel Tryggvadottir10, Alexander E Urban6, Tomas Vaisar17, Benjamin Van Espen11, Jing Zhang6, Michael G Ziegler11, Sara R Zwart20, John B Charles21, Craig E Kundrot22, Graham B I Scott23, Susan M Bailey24, Mathias Basner25, Andrew P Feinberg26, Stuart M C Lee27, Christopher E Mason28,9,29,30, Emmanuel Mignot31, Brinda K Rana32, Scott M Smith21, Michael P Snyder31, Fred W Turek33.
Abstract
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.Entities:
Mesh：
Year: 2019 PMID： 30975860 PMCID： PMC7580864 DOI： 10.1126/science.aau8650
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728