Literature DB >> 3097518

rasH mutants deficient in GTP binding.

C J Der, B T Pan, G M Cooper.   

Abstract

Single amino acid substitutions were introduced into a region of the rasH protein (residues 116, 117, and 119) homologous to a variety of diverse GTP-binding proteins. Each of the mutant p21 proteins displayed a significant reduction (10- to 5,000-fold) in GTP binding affinity. Activated rasH proteins deficient in GTP binding were unaltered in their ability to morphologically transform NIH 3T3 cells.

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Year:  1986        PMID： 3097518      PMCID： PMC367069          DOI： 10.1128/mcb.6.9.3291-3294.1986

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  39 in total

1.  Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

Authors:  J B Gibbs; I S Sigal; M Poe; E M Scolnick
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

2.  Developmental regulation of a Dictyostelium gene encoding a protein homologous to mammalian ras protein.

Authors:  C D Reymond; R H Gomer; M C Mehdy; R A Firtel
Journal:  Cell       Date:  1984-11       Impact factor: 41.582

3.  Construction and applications of a highly transmissible murine retrovirus shuttle vector.

Authors:  C L Cepko; B E Roberts; R C Mulligan
Journal:  Cell       Date:  1984-07       Impact factor: 41.582

4.  Homologies between signal transducing G proteins and ras gene products.

Authors:  J B Hurley; M I Simon; D B Teplow; J D Robishaw; A G Gilman
Journal:  Science       Date:  1984-11-16       Impact factor: 47.728

5.  Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity.

Authors:  V Manne; E Bekesi; H F Kung
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

6.  Guanosine nucleotide binding by highly purified Ha-ras-encoded p21 protein produced in Escherichia coli.

Authors:  V Manne; S Yamazaki; H F Kung
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

7.  Comparative biochemical properties of normal and activated human ras p21 protein.

Authors:  J P McGrath; D J Capon; D V Goeddel; A D Levinson
Journal:  Nature       Date:  1984 Aug 23-29       Impact factor: 49.962

8.  Sequence of the initiation factor IF2 gene: unusual protein features and homologies with elongation factors.

Authors:  C Sacerdot; P Dessen; J W Hershey; J A Plumbridge; M Grunberg-Manago
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

9.  Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template.

Authors:  M J Zoller; M Smith
Journal:  DNA       Date:  1984-12
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  28 in total

1.  Noonan syndrome: clinical aspects and molecular pathogenesis.

Authors:  M Tartaglia; G Zampino; B D Gelb
Journal:  Mol Syndromol       Date:  2010-01-15

2.  Reprogramming the purine nucleotide cofactor requirement of Drosophila P element transposase in vivo.

Authors:  Y M Mul; D C Rio
Journal:  EMBO J       Date:  1997-07-16       Impact factor: 11.598

3.  Transfection of insulin-producing cells with a transforming c-Ha-ras oncogene stimulates phospholipase C activity.

Authors:  P O Berggren; A Hallberg; N Welsh; P Arkahammar; T Nilsson; M Welsh
Journal:  Biochem J       Date:  1989-05-01       Impact factor: 3.857

4.  The large subunit of replication factor C (Rfc1p/Cdc44p) is required for DNA replication and DNA repair in Saccharomyces cerevisiae.

Authors:  M A McAlear; K M Tuffo; C Holm
Journal:  Genetics       Date:  1996-01       Impact factor: 4.562

Review 5.  The biochemistry of ras p21.

Authors:  R J Grand; D Owen
Journal:  Biochem J       Date:  1991-11-01       Impact factor: 3.857

6.  Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation.

Authors:  R Foster; K Q Hu; Y Lu; K M Nolan; J Thissen; J Settleman
Journal:  Mol Cell Biol       Date:  1996-06       Impact factor: 4.272

7.  Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.

Authors:  S M Oldham; G J Clark; L M Gangarosa; R J Coffey; C J Der
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

8.  Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins.

Authors:  L A Feig; G M Cooper
Journal:  Mol Cell Biol       Date:  1988-06       Impact factor: 4.272

9.  Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily.

Authors:  L A Quilliam; S Zhong; K M Rabun; J W Carpenter; T L South; C J Der; S Campbell-Burk
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

Review 10.  Ras oncogenes: split personalities.

Authors:  Antoine E Karnoub; Robert A Weinberg
Journal:  Nat Rev Mol Cell Biol       Date:  2008-07       Impact factor: 94.444
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