Literature DB >> 6147754

Comparative biochemical properties of normal and activated human ras p21 protein.

J P McGrath, D J Capon, D V Goeddel, A D Levinson.   

Abstract

Human Ha-ras1 cDNAs encoding normal and activated p21 polypeptides have been efficiently expressed in Escherichia coli and the biochemical activities associated with each polypeptide compared. In addition to the guanine nucleotide binding activity, normal p21 displays a GTPase activity which is selectively impaired by a mutation which activates its oncogenic potential.

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Year:  1984        PMID： 6147754     DOI： 10.1038/310644a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  195 in total

Review 1.  Molecular biology in medicine.

Authors:  B D Young
Journal:  Postgrad Med J       Date:  1992-04       Impact factor: 2.401

2.  Multiple GTP-binding proteins from cholinergic synaptic vesicles.

Authors:  J K Ngsee; K Miller; B Wendland; R H Scheller
Journal:  J Neurosci       Date:  1990-01       Impact factor: 6.167

3.  Probing the S-adenosylmethionine-binding site of rat guanidinoacetate methyltransferase. Effect of site-directed mutagenesis of residues that are conserved across mammalian non-nucleic acid methyltransferases.

Authors:  A Hamahata; Y Takata; T Gomi; M Fujioka
Journal:  Biochem J       Date:  1996-07-01       Impact factor: 3.857

Review 4.  MicroRNA-Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer.

Authors:  Sriganesh B Sharma; John Michael Ruppert
Journal:  Drug Dev Res       Date:  2015-08-18       Impact factor: 4.360

5.  Bombesin stimulation of inositol 1,4,5-trisphosphate generation and intracellular calcium release is amplified in a cell line overexpressing the N-ras proto-oncogene.

Authors:  A C Lloyd; S A Davies; I Crossley; M Whitaker; M D Houslay; A Hall; C J Marshall; M J Wakelam
Journal:  Biochem J       Date:  1989-06-15       Impact factor: 3.857

6.  Identification of an intracellular protein that specifically interacts with photoaffinity-labeled oncogenic p21 protein.

Authors:  G Lee; Z A Ronai; M R Pincus; P W Brandt-Rauf; R B Murphy; T M Delohery; S Nishimura; Z Yamaizumi; I B Weinstein
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

7.  Transfection of insulin-producing cells with a transforming c-Ha-ras oncogene stimulates phospholipase C activity.

Authors:  P O Berggren; A Hallberg; N Welsh; P Arkahammar; T Nilsson; M Welsh
Journal:  Biochem J       Date:  1989-05-01       Impact factor: 3.857

8.  Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes.

Authors:  C M Heyworth; A D Whetton; S Wong; B R Martin; M D Houslay
Journal:  Biochem J       Date:  1985-06-15       Impact factor: 3.857

9.  On ras gene function in yeast.

Authors:  D G Fraenkel
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

10.  ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins.

Authors:  D C Fry; S A Kuby; A S Mildvan
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205
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