Ida Heir Hovland1, Ingrid Sande Leikanger1, Oddbjørg Stokkeland1, Kaia Hevrøy Waage1, Svein A Mjøs2,3, Karl A Brokstad4, Adrian McCann5, Per Magne Ueland6,7, Rasa Slizyte8, Ana Carvajal8, Gunnar Mellgren6,9, Tore Remman10, Ingmar Høgøy11, Oddrun A Gudbrandsen12,13. 1. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5020, Bergen, Norway. 2. Department of Chemistry, University of Bergen, PO Box 7803, 5020, Bergen, Norway. 3. Nofima BioLab, Oasen, PO Box 1425, 5828, Bergen, Norway. 4. Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway. 5. Bevital AS, Jonas Lies veg 87, 5021, Bergen, Norway. 6. Department of Clinical Science, University of Bergen, 5021, Bergen, Norway. 7. Laboratory of Clinical Biochemistry, Haukeland University Hospital, 5021, Bergen, Norway. 8. SINTEF Ocean, Brattørkaia 17 C, 7010, Trondheim, Norway. 9. Hormone Laboratory, Haukeland University Hospital, Bergen, 5021, Bergen, Norway. 10. Nutrimar AS, Industrivei 23, 7266, Kverva, Norway. 11. Blue Protein, 5393, Storebø, Norway. 12. Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5020, Bergen, Norway. oddrun.gudbrandsen@k1.uib.no. 13. Department of Clinical Medicine, University of Bergen, Haukeland University Hospital, 5021, Bergen, Norway. oddrun.gudbrandsen@k1.uib.no.
Abstract
PURPOSE: To examine whether supplementation with low doses of fish or milk proteins would affect glucose regulation and circulating lipid concentrations in overweight healthy adults. METHODS: Ninety-three overweight adults were assigned to receive 2.5 g protein/day from herring (HER), salmon (SAL), cod (COD) or milk (CAS, a casein-whey mixture as positive control) as tablets for 8 weeks. RESULTS: Seventy-seven participants were included in the analyses. HER and SAL did not affect glucose and insulin concentrations. COD significantly reduced within-group changes in 90 and 120 min postprandial glucose concentrations but changes were not different from HER and SAL groups. CAS supplementation significantly reduced the area under the curve for glucose concentrations (- 7%), especially when compared to SAL group, and reduced postprandial insulin c-peptide concentration (- 23%). Reductions in acetoacetate (- 24%) and β-hydroxybutyrate (- 29%) serum concentrations in HER group were more prominent compared to SAL and COD groups, with no differences between fish protein groups for α-hydroxybutyrate. Serum concentrations of α-hydroxybutyrate (- 23%), acetoacetate (- 39%) and β-hydroxybutyrate (- 40%) were significantly reduced within CAS group, and the decreases were significantly more pronounced when compared to SAL group. Serum lipid concentrations were not altered in any of the intervention groups. CONCLUSION: Findings indicate that 2.5 g/day of proteins from fish or milk may be sufficient to improve glucose regulation in overweight adults. The effects were most pronounced after supplementation with proteins from cod, herring and milk, whereas salmon protein did not affect any of the measurements related to glucose regulation. CLINICAL TRAIL REGISTRATION: This trial was registered at clinicaltrials.gov as NCT01641055.
PURPOSE: To examine whether supplementation with low doses of fish or milk proteins would affect glucose regulation and circulating lipid concentrations in overweight healthy adults. METHODS: Ninety-three overweight adults were assigned to receive 2.5 g protein/day from herring (HER), salmon (SAL), cod (COD) or milk (CAS, a casein-whey mixture as positive control) as tablets for 8 weeks. RESULTS: Seventy-seven participants were included in the analyses. HER and SAL did not affect glucose and insulin concentrations. COD significantly reduced within-group changes in 90 and 120 min postprandial glucose concentrations but changes were not different from HER and SAL groups. CAS supplementation significantly reduced the area under the curve for glucose concentrations (- 7%), especially when compared to SAL group, and reduced postprandial insulin c-peptide concentration (- 23%). Reductions in acetoacetate (- 24%) and β-hydroxybutyrate (- 29%) serum concentrations in HER group were more prominent compared to SAL and COD groups, with no differences between fish protein groups for α-hydroxybutyrate. Serum concentrations of α-hydroxybutyrate (- 23%), acetoacetate (- 39%) and β-hydroxybutyrate (- 40%) were significantly reduced within CAS group, and the decreases were significantly more pronounced when compared to SAL group. Serum lipid concentrations were not altered in any of the intervention groups. CONCLUSION: Findings indicate that 2.5 g/day of proteins from fish or milk may be sufficient to improve glucose regulation in overweight adults. The effects were most pronounced after supplementation with proteins from cod, herring and milk, whereas salmon protein did not affect any of the measurements related to glucose regulation. CLINICAL TRAIL REGISTRATION: This trial was registered at clinicaltrials.gov as NCT01641055.
Entities:
Keywords:
Cod protein; Fish protein; Glucose; Herring protein hydrolysate; Milk protein; Salmon protein hydrolysate
Authors: Jose J Lara; Maria Economou; A Michael Wallace; Anne Rumley; Gordon Lowe; Christine Slater; Muriel Caslake; Naveed Sattar; Michael E J Lean Journal: Atherosclerosis Date: 2006-10-27 Impact factor: 5.162
Authors: Sheri R Colberg; Ronald J Sigal; Bo Fernhall; Judith G Regensteiner; Bryan J Blissmer; Richard R Rubin; Lisa Chasan-Taber; Ann L Albright; Barry Braun Journal: Diabetes Care Date: 2010-12 Impact factor: 19.112
Authors: Ele Ferrannini; Andrea Natali; Stefania Camastra; Monica Nannipieri; Andrea Mari; Klaus-Peter Adam; Michael V Milburn; Gabi Kastenmüller; Jerzy Adamski; Tiinamaija Tuomi; Valeriya Lyssenko; Leif Groop; Walter E Gall Journal: Diabetes Date: 2012-11-16 Impact factor: 9.461
Authors: Marit Hjorth; Natalia M Galigniana; Ola Ween; Stine M Ulven; Kirsten B Holven; Knut Tomas Dalen; Thomas Sæther Journal: Nutrients Date: 2022-04-12 Impact factor: 6.706
Authors: Caroline Jensen; Hanna F Dale; Trygve Hausken; Einar Lied; Jan G Hatlebakk; Ingeborg Brønstad; Gülen A Lied; Dag Arne L Hoff Journal: J Nutr Sci Date: 2019-12-04