Literature DB >> 30969484

Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study.

Muhammad Ehsan1,2, Ashwani Kumar1, Jonas S Mortensen3, Yang Du4, Parameswaran Hariharan5, Kaavya K Kumar4, Betty Ha4, Bernadette Byrne6, Lan Guan5, Brian K Kobilka4, Claus J Loland3, Pil Seok Chae1.   

Abstract

We prepared an amphiphile with a penta-phenylene lipophilic group and a branched trimaltoside head group. This new agent, designated penta-phenylene maltoside (PPM), showed a marked tendency to self-assembly into micelles via strong aromatic-aromatic interactions in aqueous media, as evidenced by 1 H NMR spectroscopy and fluorescence studies. When utilized for membrane protein studies, this new agent was superior to DDM, a gold standard conventional detergent, in stabilizing multiple proteins long term. The ability of this agent to form aromatic-aromatic interactions is likely responsible for enhanced protein stabilization when associated with a target membrane protein.
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  amphiphiles; membrane proteins; micelles; molecular design; protein stability; self-assembly

Mesh：

Substances：

Year:  2019        PMID： 30969484      PMCID： PMC7239035          DOI： 10.1002/asia.201900224

Source DB:  PubMed          Journal:  Chem Asian J        ISSN： 1861-471X


  41 in total

Review 1.  Solution NMR of membrane proteins: practice and challenges.

Authors:  Charles R Sanders; Frank Sönnichsen
Journal:  Magn Reson Chem       Date:  2006-07       Impact factor: 2.447

2.  Amphipols from A to Z.

Authors:  J-L Popot; T Althoff; D Bagnard; J-L Banères; P Bazzacco; E Billon-Denis; L J Catoire; P Champeil; D Charvolin; M J Cocco; G Crémel; T Dahmane; L M de la Maza; C Ebel; F Gabel; F Giusti; Y Gohon; E Goormaghtigh; E Guittet; J H Kleinschmidt; W Kühlbrandt; C Le Bon; K L Martinez; M Picard; B Pucci; J N Sachs; C Tribet; C van Heijenoort; F Wien; F Zito; M Zoonens
Journal:  Annu Rev Biophys       Date:  2011       Impact factor: 12.981

3.  A fluorinated detergent for membrane-protein applications.

Authors:  Erik Frotscher; Bartholomäus Danielczak; Carolyn Vargas; Annette Meister; Grégory Durand; Sandro Keller
Journal:  Angew Chem Int Ed Engl       Date:  2015-03-09       Impact factor: 15.336

4.  Carbohydrate-coated supramolecular structures: transformation of nanofibers into spherical micelles triggered by guest encapsulation.

Authors:  Ja-Hyoung Ryu; Eunji Lee; Yong-beom Lim; Myongsoo Lee
Journal:  J Am Chem Soc       Date:  2007-03-24       Impact factor: 15.419

5.  Quinone reduction via secondary B-branch electron transfer in mutant bacterial reaction centers.

Authors:  Philip D Laible; Christine Kirmaier; Chandani S M Udawatte; Samuel J Hofman; Dewey Holten; Deborah K Hanson
Journal:  Biochemistry       Date:  2003-02-18       Impact factor: 3.162

6.  Self-assembling molecular trees containing octa-p-phenylene: from nanocrystals to nanocapsules.

Authors:  Yong-Sik Yoo; Jin-Ho Choi; Ji-Ho Song; Nam-Keun Oh; Wang-Cheol Zin; Soojin Park; Taihyun Chang; Myongsoo Lee
Journal:  J Am Chem Soc       Date:  2004-05-26       Impact factor: 15.419

7.  Microscale fluorescent thermal stability assay for membrane proteins.

Authors:  Alexander I Alexandrov; Mauro Mileni; Ellen Y T Chien; Michael A Hanson; Raymond C Stevens
Journal:  Structure       Date:  2008-03       Impact factor: 5.006

8.  Hydrophobic variants of ganglio-tripod amphiphiles for membrane protein manipulation.

Authors:  Pil Seok Chae; Kyung Ho Cho; Marc J Wander; Hyoung Eun Bae; Samuel H Gellman; Philip D Laible
Journal:  Biochim Biophys Acta       Date:  2013-09-21

9.  Molecular self-assembly into one-dimensional nanostructures.

Authors:  Liam C Palmer; Samuel I Stupp
Journal:  Acc Chem Res       Date:  2008-12       Impact factor: 22.384

10.  Insights into outer membrane protein crystallization.

Authors:  Simon Newstead; Jeanette Hobbs; Davina Jordan; Elisabeth P Carpenter; So Iwata
Journal:  Mol Membr Biol       Date:  2008-12       Impact factor: 2.857
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  2 in total

1.  New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability.

Authors:  Muhammad Ehsan; Satoshi Katsube; Cristina Cecchetti; Yang Du; Jonas S Mortensen; Haoqing Wang; Andreas Nygaard; Lubna Ghani; Claus J Loland; Brian K Kobilka; Bernadette Byrne; Lan Guan; Pil Seok Chae
Journal:  ACS Chem Biol       Date:  2020-06-05       Impact factor: 5.100

2.  Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability.

Authors:  Muhammad Ehsan; Haoqing Wang; Cristina Cecchetti; Jonas S Mortensen; Yang Du; Parameswaran Hariharan; Andreas Nygaard; Ho Jin Lee; Lubna Ghani; Lan Guan; Claus J Loland; Bernadette Byrne; Brian K Kobilka; Pil Seok Chae
Journal:  ACS Chem Biol       Date:  2021-08-26       Impact factor: 4.634
  2 in total

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