| Literature DB >> 30962619 |
Marco Maccaferri1,2, Neil S Harris3, Sven O Twardziok4, Raj K Pasam5, Heidrun Gundlach4, Manuel Spannagl4, Danara Ormanbekova1,4, Thomas Lux4, Verena M Prade4, Sara G Milner6, Axel Himmelbach6, Martin Mascher6,7, Paolo Bagnaresi8, Primetta Faccioli8, Paolo Cozzi9, Massimiliano Lauria9, Barbara Lazzari9, Alessandra Stella9, Andrea Manconi10, Matteo Gnocchi10, Marco Moscatelli10, Raz Avni11, Jasline Deek11, Sezgi Biyiklioglu12, Elisabetta Frascaroli1, Simona Corneti1, Silvio Salvi1, Gabriella Sonnante13, Francesca Desiderio8, Caterina Marè8, Cristina Crosatti8, Erica Mica8, Hakan Özkan14, Benjamin Kilian15, Pasquale De Vita2, Daniela Marone2, Reem Joukhadar5,16, Elisabetta Mazzucotelli8, Domenica Nigro17, Agata Gadaleta18, Shiaoman Chao19, Justin D Faris19, Arthur T O Melo20, Mike Pumphrey21, Nicola Pecchioni2, Luciano Milanesi10, Krystalee Wiebe22, Jennifer Ens22, Ron P MacLachlan22, John M Clarke22, Andrew G Sharpe23, Chu Shin Koh23, Kevin Y H Liang3, Gregory J Taylor3, Ron Knox24, Hikmet Budak12, Anna M Mastrangelo2,25, Steven S Xu19, Nils Stein6, Iago Hale20, Assaf Distelfeld11, Matthew J Hayden5,26, Roberto Tuberosa1, Sean Walkowiak22, Klaus F X Mayer27,28, Aldo Ceriotti29, Curtis J Pozniak30, Luigi Cattivelli31.
Abstract
The domestication of wild emmer wheat led to the selection of modern durum wheat, grown mainly for pasta production. We describe the 10.45 gigabase (Gb) assembly of the genome of durum wheat cultivar Svevo. The assembly enabled genome-wide genetic diversity analyses revealing the changes imposed by thousands of years of empirical selection and breeding. Regions exhibiting strong signatures of genetic divergence associated with domestication and breeding were widespread in the genome with several major diversity losses in the pericentromeric regions. A locus on chromosome 5B carries a gene encoding a metal transporter (TdHMA3-B1) with a non-functional variant causing high accumulation of cadmium in grain. The high-cadmium allele, widespread among durum cultivars but undetected in wild emmer accessions, increased in frequency from domesticated emmer to modern durum wheat. The rapid cloning of TdHMA3-B1 rescues a wild beneficial allele and demonstrates the practical use of the Svevo genome for wheat improvement.Entities:
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Year: 2019 PMID： 30962619 DOI： 10.1038/s41588-019-0381-3
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330