| Literature DB >> 30962294 |
Renée F de Pooter1,2, Sheila Dias1,2, Munmun Chowdhury1,2, Elisabeth T Bartom3, Michael K Okoreeh2,4, Mikael Sigvardsson5, Barbara L Kee6,2.
Abstract
Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.Entities:
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Year: 2019 PMID： 30962294 PMCID： PMC6504590 DOI： 10.4049/jimmunol.1801220
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422