Literature DB >> 10446057

Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2.

W Yu1, Z Misulovin, H Suh, R R Hardy, M Jankovic, N Yannoutsos, M C Nussenzweig.   

Abstract

RAG1 and RAG2 are essential for V(D)J recombination and lymphocyte development. These genes are thought to encode a transposase derived from a mobile genetic element that was inserted into the vertebrate genome 450 million years ago. The regulation of RAG1 and RAG2 was investigated in vivo with bacterial artificial chromosome (BAC) transgenes containing a fluorescent indicator. Coordinate expression of RAG1 and RAG2 in B and T cells was found to be regulated by distinct genetic elements found on the 5' side of the RAG2 gene. This observation suggests a mechanism by which asymmetrically disposed cis DNA elements could influence the expression of the primordial transposon and thereby capture RAGs for vertebrate evolution.

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Year:  1999        PMID： 10446057     DOI： 10.1126/science.285.5430.1080

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  55 in total

1.  RAG2 is regulated differentially in B and T cells by elements 5' of the promoter.

Authors:  R J Monroe; F Chen; R Ferrini; L Davidson; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

2.  c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells.

Authors:  Q F Wang; J Lauring; M S Schlissel
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

3.  Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication.

Authors:  Shiaoching Gong; Xiangdong William Yang; Chenjian Li; Nathaniel Heintz
Journal:  Genome Res       Date:  2002-12       Impact factor: 9.043

4.  In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.

Authors:  David M Langenau; Adolfo A Ferrando; David Traver; Jeffery L Kutok; John-Paul D Hezel; John P Kanki; Leonard I Zon; A Thomas Look; Nikolaus S Trede
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-03       Impact factor: 11.205

5.  Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1.

Authors:  Renée F de Pooter; Sheila Dias; Munmun Chowdhury; Elisabeth T Bartom; Michael K Okoreeh; Mikael Sigvardsson; Barbara L Kee
Journal:  J Immunol       Date:  2019-04-08       Impact factor: 5.422

6.  Adapting in vitro embryonic stem cell differentiation to the study of locus control regions.

Authors:  Armin Lahiji; Martina Kučerová-Levisohn; Roxanne Holmes; Juan Carlos Zúñiga-Pflücker; Benjamin D Ortiz
Journal:  J Immunol Methods       Date:  2014-03-26       Impact factor: 2.303

7.  A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.

Authors:  Laurent Verkoczy; Djemel Aït-Azzouzene; Patrick Skog; Annica Märtensson; Julie Lang; Bao Duong; David Nemazee
Journal:  Immunity       Date:  2005-04       Impact factor: 31.745

8.  Revision of T cell receptor {alpha} chain genes is required for normal T lymphocyte development.

Authors:  Ching-Yu Huang; Barry P Sleckman; Osami Kanagawa
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-26       Impact factor: 11.205

Review 9.  From B cell to plasma cell: regulation of V(D)J recombination and antibody secretion.

Authors:  Lisa Borghesi; Christine Milcarek
Journal:  Immunol Res       Date:  2006       Impact factor: 2.829

10.  Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.

Authors:  Laurent Verkoczy; Bao Duong; Patrick Skog; Djemel Aït-Azzouzene; Kamal Puri; José Luis Vela; David Nemazee
Journal:  J Immunol       Date:  2007-05-15       Impact factor: 5.422
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