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Literature DB >> 12203546

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.

Vsevolod V Rostovtsev¹, Luke G Green, Valery V Fokin, K Barry Sharpless.

Abstract

Entities: Chemical

Mesh：

Substances：
Alkynes
Azides
Copper

Year: 2002 PMID： 12203546 DOI： 10.1002/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.

1. Fully functionalized small-molecule probes for integrated phenotypic screening and target identification.

2. A biosynthetic strategy for re-engineering the Staphylococcus aureus cell wall with non-native small molecules.

Review 3. Recent strategies targeting HIV glycans in vaccine design.

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5. Long-living RNA in the CNS of terrestrial snail.

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