Mingming Wang1, Meicen Liu2, Cairu Wang1, Yue Xiao1, Tong An1, Meijuan Zou3, Gang Cheng4. 1. School of Life Sciences and Biopharmaceutis, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China. 2. Department of Respiratory, General Hospital of Shenyang Military Area, Shenhe District, Shenyang, 110016, Liaoning, China. 3. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China. 4. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China. Electronic address: chenggang63@hotmail.com.
Abstract
BACKGROUND: There is a controversy in terms of the efficacy of vitamin D supplementation in improving asthma symptom control. Moreover, whether there is a difference in the treatment effect with respect to baseline vitamin D status remains unknown. This meta-analysis was to assess the correlations of vitamin D status with asthma-related respiratory outcomes. METHODS: PubMed, EMBASE, and Cochrane Library were searched for randomized controlled trials of vitamin D supplementation in patients with asthma. Primary outcomes were the rate of asthma exacerbation and predicted percentage of forced expiratory volume in first second (FEV1%). Secondary outcomes were asthma control test (ACT) scores, fractional exhaled nitric oxide (FeNO), interleukin-10 (IL-10) and adverse events. RESULTS: A total of 14 randomized controlled trials (1421 participants) fulfilled the inclusion. Vitamin D supplementation was associated with a significant reduction in the rate of asthma exacerbation by 27% (RR: 0.73 95%Cl (0.58-0.92)). In subgroup analysis, the protective effect of exacerbation was restricted in patients with vitamin D insufficiency (vitamin D < 30 ng/ml) (RR: 0.76 95%Cl (0.61-0.95)). An improvement of FEV1% was demonstrated in patients with vitamin D insufficiency and air limitation (FEV1% < 80%) (MD: 8.3 95%Cl (5.95-10.64). No significant difference was observed in ACT scores, FeNO, IL-10 and adverse events. CONCLUSIONS: Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. Additionally, the benefit of vitamin D had a positive effect on pulmonary function in patients with air limitation and vitamin D insufficiency.
BACKGROUND: There is a controversy in terms of the efficacy of vitamin D supplementation in improving asthma symptom control. Moreover, whether there is a difference in the treatment effect with respect to baseline vitamin D status remains unknown. This meta-analysis was to assess the correlations of vitamin D status with asthma-related respiratory outcomes. METHODS: PubMed, EMBASE, and Cochrane Library were searched for randomized controlled trials of vitamin D supplementation in patients with asthma. Primary outcomes were the rate of asthma exacerbation and predicted percentage of forced expiratory volume in first second (FEV1%). Secondary outcomes were asthma control test (ACT) scores, fractional exhaled nitric oxide (FeNO), interleukin-10 (IL-10) and adverse events. RESULTS: A total of 14 randomized controlled trials (1421 participants) fulfilled the inclusion. Vitamin D supplementation was associated with a significant reduction in the rate of asthma exacerbation by 27% (RR: 0.73 95%Cl (0.58-0.92)). In subgroup analysis, the protective effect of exacerbation was restricted in patients with vitamin Dinsufficiency (vitamin D < 30 ng/ml) (RR: 0.76 95%Cl (0.61-0.95)). An improvement of FEV1% was demonstrated in patients with vitamin Dinsufficiency and air limitation (FEV1% < 80%) (MD: 8.3 95%Cl (5.95-10.64). No significant difference was observed in ACT scores, FeNO, IL-10 and adverse events. CONCLUSIONS:Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin Dinsufficiency. Additionally, the benefit of vitamin D had a positive effect on pulmonary function in patients with air limitation and vitamin Dinsufficiency.
Authors: Theresa W Guilbert; Jocelyn M Biagini; Rachelle R Ramsey; Kristina Keidel; Kristi Curtsinger; John W Kroner; Sandy R Durrani; Mariana Stevens; Valentina Pilipenko; Lisa J Martin; Carolyn M Kercsmar; Kevin Hommel; Gurjit K Khurana Hershey Journal: Ann Allergy Asthma Immunol Date: 2022-02-03 Impact factor: 6.248
Authors: Alana Alcântara Galvão; Flávia de Araújo Sena; Emília Maria Medeiros de Andrade Belitardo; Maria Borges Rabelo de Santana; Gustavo Nunes de Oliveira Costa; Álvaro Augusto Cruz; Maurício Lima Barreto; Ryan Dos Santos Costa; Neuza Maria Alcantara-Neves; Camila Alexandrina Figueiredo Journal: Allergy Asthma Clin Immunol Date: 2020-07-09 Impact factor: 3.406