Marie Chas1, Caroline Goupille2, Flavie Arbion3, Philippe Bougnoux4, Michelle Pinault2, Marie Lise Jourdan2, Stephan Chevalier2, Lobna Ouldamer5. 1. Department of Gynecology, Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau. 2 Boulevard Tonnellé, 37044, Tours, France; INSERM UMR1069 « Nutrition, Growth and Cancer », 10 Boulevard Tonnellé, 37032, Tours, France; University of Tours, 10 Boulevard Tonnellé, 37032, Tours, France. 2. INSERM UMR1069 « Nutrition, Growth and Cancer », 10 Boulevard Tonnellé, 37032, Tours, France; University of Tours, 10 Boulevard Tonnellé, 37032, Tours, France. 3. Department of Pathology, Centre Hospitalier Régional Universitaire de Tours. Hôpital Bretonneau, 2 Boulevard Tonnellé, Tours, France. 4. INSERM UMR1069 « Nutrition, Growth and Cancer », 10 Boulevard Tonnellé, 37032, Tours, France; University of Tours, 10 Boulevard Tonnellé, 37032, Tours, France; Department of Oncology, Centre Hospitalier Régional Universitaire de Tours. Hôpital Bretonneau, 2 Boulevard Tonnellé, Tours, France. 5. Department of Gynecology, Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau. 2 Boulevard Tonnellé, 37044, Tours, France; INSERM UMR1069 « Nutrition, Growth and Cancer », 10 Boulevard Tonnellé, 37032, Tours, France; University of Tours, 10 Boulevard Tonnellé, 37032, Tours, France. Electronic address: l.ouldamer@chu-tours.fr.
Abstract
OBJECTIVE: Since it is thought that breast adipose tissue could influence breast cancer clinical presentation, we wanted to characterize specifically the relationship between breast adipose tissue fatty acid profile and Inflammatory Breast cancer (IBC). METHODS: Two hundred thirty-four women presenting with breast cancer were managed in our centre between January 2009 and December 2011. Breast adipose tissue specimens were collected during breast surgery. We established the biochemical profile of adipose tissue fatty acids (FA) by gas chromatography and assessed whether there were differences in function of the presence of breast inflammation or not. RESULTS: We found that IBC was associated with decreased levels in breast adipose tissue of eicosapentaenoic acid (EPA), one of the two main polyunsaturated n-3 fatty acids (n-3 PUFA) of marine origin, but also with decreased levels of Gamma Linolenic acid (GLA). Inversely, an increase in palmitic acid levels was associated with IBC. CONCLUSION: These differences in lipid content may contribute to the occurrence of breast cancer inflammation.
OBJECTIVE: Since it is thought that breast adipose tissue could influence breast cancer clinical presentation, we wanted to characterize specifically the relationship between breast adipose tissue fatty acid profile and Inflammatory Breast cancer (IBC). METHODS: Two hundred thirty-four women presenting with breast cancer were managed in our centre between January 2009 and December 2011. Breast adipose tissue specimens were collected during breast surgery. We established the biochemical profile of adipose tissue fatty acids (FA) by gas chromatography and assessed whether there were differences in function of the presence of breast inflammation or not. RESULTS: We found that IBC was associated with decreased levels in breast adipose tissue of eicosapentaenoic acid (EPA), one of the two main polyunsaturated n-3 fatty acids (n-3 PUFA) of marine origin, but also with decreased levels of Gamma Linolenic acid (GLA). Inversely, an increase in palmitic acid levels was associated with IBC. CONCLUSION: These differences in lipid content may contribute to the occurrence of breast cancer inflammation.
Authors: Feng Zhuang; Xuesong Bai; Yang Shi; Le Chang; Wanchao Ai; Juan Du; Wei Liu; Humin Liu; Xukun Zhou; Zhong Wang; Tao Hong Journal: Front Surg Date: 2022-08-25