Argita D Salindri1, Sara C Auld2, Marcos C Schechter3, Neel R Gandhi4, Matthew J Magee5. 1. Division of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, GA. Electronic address: asalindri1@student.gsu.edu. 2. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Department of Epidemiology, School of Medicine, Rollins School of Public Health, Emory University, Atlanta, GA. 3. Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA. 4. Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA; Departments of Epidemiology and Global Health, Emory University Rollins School of Public Health, Atlanta, GA. 5. Division of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, GA; Departments of Epidemiology and Global Health, Emory University Rollins School of Public Health, Atlanta, GA.
Abstract
PURPOSE: The purpose of this study was to determine if a negative tuberculin skin test (TST) result is associated with increased risk of mortality during tuberculosis (TB) treatment. METHODS: We conducted a retrospective cohort study among patients aged ≥15 years with culture-positive TB reported to the Georgia State Electronic Notifiable Disease Surveillance System from 2009 to 2014. TST positivity was defined by the US Centers for Disease Control guidelines. All-cause mortality during TB treatment as well as HIV, diabetes, and end-stage renal disease status were collected from surveillance data. Log-binomial regression was used to estimate adjusted risk ratios and 95% confidence intervals. RESULTS: Among 1186 culture-confirmed TB patients, 780 (65.8%) with a valid TST and TB treatment outcomes were eligible. Nearly one-third (242/780) had a negative TST result, and 5.6% died during treatment. The highest risk of death was observed among patients with a negative TST and HIV (12.5%) and a negative TST and diabetes (15.4%). Adjusting for confounders, the risk of death among patients with a negative TST was significantly greater compared with those with a positive TST (adjusted risk ratio 2.33 95% confidence interval 1.23-4.43). CONCLUSIONS: A negative TST was associated with more than twice the risk of mortality during TB treatment after adjusting for immunosuppressive conditions.
PURPOSE: The purpose of this study was to determine if a negative tuberculin skin test (TST) result is associated with increased risk of mortality during tuberculosis (TB) treatment. METHODS: We conducted a retrospective cohort study among patients aged ≥15 years with culture-positive TB reported to the Georgia State Electronic Notifiable Disease Surveillance System from 2009 to 2014. TST positivity was defined by the US Centers for Disease Control guidelines. All-cause mortality during TB treatment as well as HIV, diabetes, and end-stage renal disease status were collected from surveillance data. Log-binomial regression was used to estimate adjusted risk ratios and 95% confidence intervals. RESULTS: Among 1186 culture-confirmed TB patients, 780 (65.8%) with a valid TST and TB treatment outcomes were eligible. Nearly one-third (242/780) had a negative TST result, and 5.6% died during treatment. The highest risk of death was observed among patients with a negative TST and HIV (12.5%) and a negative TST and diabetes (15.4%). Adjusting for confounders, the risk of death among patients with a negative TST was significantly greater compared with those with a positive TST (adjusted risk ratio 2.33 95% confidence interval 1.23-4.43). CONCLUSIONS: A negative TST was associated with more than twice the risk of mortality during TB treatment after adjusting for immunosuppressive conditions.
Authors: Argita D Salindri; Rose-Marie F Sales; Lauren DiMiceli; Marcos C Schechter; Russell R Kempker; Matthew J Magee Journal: Ann Am Thorac Soc Date: 2018-03
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