Literature DB >> 30951661

Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function.

Marjorie Brand1, Kiran Nakka2, Jiayu Zhu2, F Jeffrey Dilworth3.   

Abstract

Stem cells are continuously challenged with the decision to either self-renew or adopt a new fate. Self-renewal is regulated by a system of cellular memory, which must be bypassed for differentiation. Previous studies have identified Polycomb group (PcG) and Trithorax group (TrxG) proteins as key modulators of cellular memory. In this Perspective, we draw from embryonic and adult stem cell studies to discuss the complex roles played by PcG and TrxG in maintaining cell identity while allowing for microenvironment-mediated alterations in cell fate. Finally, we discuss the potential for targeting these proteins as a therapeutic approach in cancer.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Ezh2; Polycomb; Trithorax; UTX; cell fate; cellular memory; epigenetics; histone methylation; leukemia; transcription factors

Mesh：

Substances：

Year:  2019        PMID： 30951661      PMCID： PMC6866673          DOI： 10.1016/j.stem.2019.03.005

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  165 in total

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Authors:  Aline Roch; Vincent Trachsel; Matthias P Lutolf
Journal:  Stem Cells       Date:  2015-08-06       Impact factor: 6.277

2.  Splicing of Ezh1 gets muscle out of stressful situations.

Authors:  Marjorie Brand; F Jeffrey Dilworth
Journal:  Nat Struct Mol Biol       Date:  2017-05-04       Impact factor: 15.369

3.  UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.

Authors:  Chaochen Wang; Ji-Eun Lee; Young-Wook Cho; Ying Xiao; Qihuang Jin; Chengyu Liu; Kai Ge
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-04       Impact factor: 11.205

4.  UTX promotes hormonally responsive breast carcinogenesis through feed-forward transcription regulation with estrogen receptor.

Authors:  G Xie; X Liu; Y Zhang; W Li; S Liu; Z Chen; B Xu; J Yang; L He; Z Zhang; T Jin; X Yi; L Sun; Y Shang; J Liang
Journal:  Oncogene       Date:  2017-05-22       Impact factor: 9.867

5.  A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.

Authors:  Tobias Berg; Silvia Thoene; Damian Yap; Tracee Wee; Nathalie Schoeler; Patty Rosten; Emilia Lim; Misha Bilenky; Andrew J Mungall; Thomas Oellerich; Sherry Lee; Courteney K Lai; Patricia Umlandt; Anisa Salmi; Harry Chang; Lisa Yue; David Lai; S-W Grace Cheng; Ryan D Morin; Martin Hirst; Hubert Serve; Marco A Marra; Gregg B Morin; Randy D Gascoyne; Samuel A Aparicio; R Keith Humphries
Journal:  Blood       Date:  2014-05-06       Impact factor: 22.113

6.  EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.

Authors:  Wendy Béguelin; Relja Popovic; Matt Teater; Yanwen Jiang; Karen L Bunting; Monica Rosen; Hao Shen; Shao Ning Yang; Ling Wang; Teresa Ezponda; Eva Martinez-Garcia; Haikuo Zhang; Yupeng Zheng; Sharad K Verma; Michael T McCabe; Heidi M Ott; Glenn S Van Aller; Ryan G Kruger; Yan Liu; Charles F McHugh; David W Scott; Young Rock Chung; Neil Kelleher; Rita Shaknovich; Caretha L Creasy; Randy D Gascoyne; Kwok-Kin Wong; Leandro Cerchietti; Ross L Levine; Omar Abdel-Wahab; Jonathan D Licht; Olivier Elemento; Ari M Melnick
Journal:  Cancer Cell       Date:  2013-05-13       Impact factor: 31.743

7.  UTX demethylase activity is required for satellite cell-mediated muscle regeneration.

Authors:  Hervé Faralli; Chaochen Wang; Kiran Nakka; Aissa Benyoucef; Soji Sebastian; Lenan Zhuang; Alphonse Chu; Carmen G Palii; Chengyu Liu; Brendan Camellato; Marjorie Brand; Kai Ge; F Jeffrey Dilworth
Journal:  J Clin Invest       Date:  2016-03-21       Impact factor: 14.808

Review 8.  Protein Kinases in Pluripotency-Beyond the Usual Suspects.

Authors:  Rosalia Fernandez-Alonso; Francisco Bustos; Charles A C Williams; Greg M Findlay
Journal:  J Mol Biol       Date:  2017-04-26       Impact factor: 5.469

9.  Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

Authors:  Kristel M Dorighi; Tomek Swigut; Telmo Henriques; Natarajan V Bhanu; Benjamin S Scruggs; Nataliya Nady; Christopher D Still; Benjamin A Garcia; Karen Adelman; Joanna Wysocka
Journal:  Mol Cell       Date:  2017-05-05       Impact factor: 17.970

10.  Bmi1 is expressed in postnatal myogenic satellite cells, controls their maintenance and plays an essential role in repeated muscle regeneration.

Authors:  Lesley G Robson; Valentina Di Foggia; Aleksandar Radunovic; Katy Bird; Xinyu Zhang; Silvia Marino
Journal:  PLoS One       Date:  2011-11-09       Impact factor: 3.240
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  18 in total

Review 1.  Dynamic Competition of Polycomb and Trithorax in Transcriptional Programming.

Authors:  Mitzi I Kuroda; Hyuckjoon Kang; Sandip De; Judith A Kassis
Journal:  Annu Rev Biochem       Date:  2020-01-13       Impact factor: 23.643

2.  Hemogen/BRG1 cooperativity modulates promoter and enhancer activation during erythropoiesis.

Authors:  Xiang Guo; Yangu Zhao; Juhyun Kim; Ann Dean
Journal:  Blood       Date:  2022-06-16       Impact factor: 25.476

3.  The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters.

Authors:  Mengjie Liu; Yaru Zhu; Fei Xing; Shuang Liu; Yin Xia; Qing Jiang; Jinzhong Qin
Journal:  J Biol Chem       Date:  2020-06-01       Impact factor: 5.157

4.  Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis.

Authors:  Mark A Gillespie; Carmen G Palii; Daniel Sanchez-Taltavull; Paul Shannon; William J R Longabaugh; Damien J Downes; Karthi Sivaraman; Herbert M Espinoza; Jim R Hughes; Nathan D Price; Theodore J Perkins; Jeffrey A Ranish; Marjorie Brand
Journal:  Mol Cell       Date:  2020-04-23       Impact factor: 17.970

Review 5.  The control of polycomb repressive complexes by long noncoding RNAs.

Authors:  Jackson B Trotman; Keean C A Braceros; Rachel E Cherney; McKenzie M Murvin; J Mauro Calabrese
Journal:  Wiley Interdiscip Rev RNA       Date:  2021-04-16       Impact factor: 9.957

Review 6.  Single-cell fate decisions of bipotential hematopoietic progenitors.

Authors:  Marjorie Brand; Edward Morrissey
Journal:  Curr Opin Hematol       Date:  2020-07       Impact factor: 3.218

7.  MLL1 is required for PAX7 expression and satellite cell self-renewal in mice.

Authors:  Gregory C Addicks; Caroline E Brun; Marie-Claude Sincennes; John Saber; Christopher J Porter; A Francis Stewart; Patricia Ernst; Michael A Rudnicki
Journal:  Nat Commun       Date:  2019-09-18       Impact factor: 14.919

8.  Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells.

Authors:  Helen M Tauc; Imilce A Rodriguez-Fernandez; Jason A Hackney; Michal Pawlak; Tal Ronnen Oron; Jerome Korzelius; Hagar F Moussa; Subhra Chaudhuri; Zora Modrusan; Bruce A Edgar; Heinrich Jasper
Journal:  Elife       Date:  2021-03-16       Impact factor: 8.140

9.  Boundaries potentiate polycomb response element-mediated silencing.

Authors:  Maksim Erokhin; Fedor Gorbenko; Dmitry Lomaev; Marina Yu Mazina; Anna Mikhailova; Azat K Garaev; Aleksander Parshikov; Nadezhda E Vorobyeva; Pavel Georgiev; Paul Schedl; Darya Chetverina
Journal:  BMC Biol       Date:  2021-06-02       Impact factor: 7.431

Review 10.  Transcriptional reprogramming in neonatal hematopoietic stem and progenitor cells.

Authors:  Yanan Li; Jeffrey A Magee
Journal:  Exp Hematol       Date:  2021-07-23       Impact factor: 3.249
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