A computational-observer model of spatial contrast sensitivity: Effects of wave-front-based optics, cone-mosaic structure, and inference engine.

We present a computational-observer model of the human spatial contrast-sensitivity function based on the Image Systems Engineering Toolbox for Biology (ISETBio) simulation framework. We demonstrate that ISETBio-derived contrast-sensitivity functions agree well with ones derived using traditional ideal-observer approaches, when the mosaic, optics, and inference engine are matched. Further simulations extend earlier work by considering more realistic cone mosaics, more recent measurements of human physiological optics, and the effect of varying the inference engine used to link visual representations to psychophysical performance. Relative to earlier calculations, our simulations show that the spatial structure of realistic cone mosaics reduces the upper bounds on performance at low spatial frequencies, whereas realistic optics derived from modern wave-front measurements lead to increased upper bounds at high spatial frequencies. Finally, we demonstrate that the type of inference engine used has a substantial effect on the absolute level of predicted performance. Indeed, the performance gap between an ideal observer with exact knowledge of the relevant signals and human observers is greatly reduced when the inference engine has to learn aspects of the visual task. ISETBio-derived estimates of stimulus representations at various stages along the visual pathway provide a powerful tool for computing the limits of human performance.