BACKGROUND: In 2017, the Democratic Republic of the Congo (DRC) recorded its eighth Ebola virus disease (EVD) outbreak, approximately 3 years after the previous outbreak. METHODS: Suspect cases of EVD were identified on the basis of clinical and epidemiological information. Reverse transcription-polymerase chain reaction (RT-PCR) analysis or serological testing was used to confirm Ebola virus infection in suspected cases. The causative virus was later sequenced from a RT-PCR-positive individual and assessed using phylogenetic analysis. RESULTS: Three probable and 5 laboratory-confirmed cases of EVD were recorded between 27 March and 1 July 2017 in the DRC. Fifty percent of cases died from the infection. EVD cases were detected in 4 separate areas, resulting in > 270 contacts monitored. The complete genome of the causative agent, a variant from the Zaireebolavirus species, denoted Ebola virus Muyembe, was obtained using next-generation sequencing. This variant is genetically closest, with 98.73% homology, to the Ebola virus Mayinga variant isolated from the first DRC outbreaks in 1976-1977. CONCLUSION: A single spillover event into the human population is responsible for this DRC outbreak. Human-to-human transmission resulted in limited dissemination of the causative agent, a novel Ebola virus variant closely related to the initial Mayinga variant isolated in 1976-1977 in the DRC.
BACKGROUND: In 2017, the Democratic Republic of the Congo (DRC) recorded its eighth Ebola virus disease (EVD) outbreak, approximately 3 years after the previous outbreak. METHODS: Suspect cases of EVD were identified on the basis of clinical and epidemiological information. Reverse transcription-polymerase chain reaction (RT-PCR) analysis or serological testing was used to confirm Ebola virus infection in suspected cases. The causative virus was later sequenced from a RT-PCR-positive individual and assessed using phylogenetic analysis. RESULTS: Three probable and 5 laboratory-confirmed cases of EVD were recorded between 27 March and 1 July 2017 in the DRC. Fifty percent of cases died from the infection. EVD cases were detected in 4 separate areas, resulting in > 270 contacts monitored. The complete genome of the causative agent, a variant from the Zaireebolavirus species, denoted Ebola virus Muyembe, was obtained using next-generation sequencing. This variant is genetically closest, with 98.73% homology, to the Ebola virus Mayinga variant isolated from the first DRC outbreaks in 1976-1977. CONCLUSION: A single spillover event into the human population is responsible for this DRC outbreak. Human-to-human transmission resulted in limited dissemination of the causative agent, a novel Ebola virus variant closely related to the initial Mayinga variant isolated in 1976-1977 in the DRC.
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Authors: Sophie Gryseels; Placide Mbala-Kingebeni; Innocent Akonda; Roger Angoyo; Ahidjo Ayouba; Pascal Baelo; Daniel Bamuleka Mukadi; Elie Bugentho; Trenton Bushmaker; Christelle Butel; Sébastien Calvignac-Spencer; Eric Delaporte; Birgit De Smet; Ariane Düx; François Edidi-Atani; Robert Fischer; Corneille Kahandi; Jimmy Kapetshi; Servet Kimbonza Sumba; Léonce Kouadio; André Malekani Bendeke; Claude Mande; Guy Midingi Sepolo; Joseph Moudindo; Eitel Mpoudi Ngole; Prescott Musaba; Patrick Mutombo; Innocent Ndong Bass; Casimir Nebesse; Steve Ngoy; Simon-Pierre Ndimbo Kumogo; Stephanie N Seifert; Jacques Tanzito; Dudu Akaibe; Nicaise Amundala; Kevin K Ariën; Guy-Crispin Gembu; Fabian H Leendertz; Herwig Leirs; Jean-Claude Mukinzi; Vincent Munster; Jean-Jacques Muyembe-Tamfum; Martine Peeters; Erik Verheyen; Steve Ahuka-Mundeke Journal: Emerg Infect Dis Date: 2020-09 Impact factor: 6.883
Authors: Kathryn E L Grimes; Bonaventure Fuamba Ngoyi; Kristen B Stolka; Jennifer J Hemingway-Foday; Leopold Lubula; Mathias Mossoko; Antoine Okitandjate; Pia D M MacDonald; Amy Nelson; Sarah Rhea; Benoit Kebela Ilunga Journal: Front Public Health Date: 2020-08-04
Authors: Brett F Beitzel; Sheli R Radoshitzky; Nicholas Di Paola; Jennifer M Brannan; David Kimmel; Katie Caviness; Veronica Soloveva; Shuiqing Yu; Elena N Postnikova; Courtney L Finch; Hu Liu; Laura Prugar; Russell Bakken; John M Dye; Jeffrey R Kugelman; James M Cunningham; Mariano Sanchez-Lockhart; Jens H Kuhn; Gustavo Palacios Journal: Viruses Date: 2021-10-06 Impact factor: 5.048