Alba Fiorentino1, Riccardo Laudicella2, Elisa Ciurlia3, Salvatore Annunziata4, Valentina Lancellotta5, Paola Mapelli6, Carmelo Tuscano7, Federico Caobelli8, Laura Evangelista9, Lorenza Marino10, Natale Quartuccio11, Michele Fiore12, Paolo Borghetti13, Agostino Chiaravalloti14, Maria Ricci15, Isacco Desideri16, Pierpaolo Alongi17. 1. Radiotherapy Oncology Department, General Regional Hospital "F. Miulli", Acquaviva delle Fonti-Bari, Italy. Electronic address: a.fiorentino@miulli.it. 2. Department of Biomedical and Dental Sciences and of Morphofunctional Imaging, University of Messina, Italy. 3. Radiotherapy Oncology Department, Vito Fazzi Hospital, Lecce, Italy. 4. Fondazione Policlinico A. Gemelli IRCCS-Università Cattolica Sacro Cuore, Roma, Italy. 5. Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Radioterapia, Dipartimento di Scienze Radiologiche, Radioterapiche ed Ematologiche, Roma, Italy. 6. Department of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy. 7. Radiotherapy Oncology Department, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, Italy. 8. Clinic of Radiology and Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland. 9. Nuclear Medicine Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. 10. Radiotherapy Oncology Department, REM, Viagrande, Catania, Italy. 11. Nuclear Medicine Unit, ARNAS Civico Palermo, Palermo, Italy. 12. Radiation Oncology, Campus Bio-Medico University, Rome, Italy. 13. Radiation Oncology Department University and Spedali Civili, Brescia, Italy. 14. IRCCS Istituto Neurologico Mediterraneo (INM) Neuromed, Pozzilli, Italy; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Italy. 15. Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy. 16. Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", Section of Radiation Oncology, University of Florence, Italy. 17. Department of Radiological Sciences, Nuclear Medicine Service, Fondazione Istituto G. Giglio, Cefalu, Italy.
Abstract
AIM: Positron Emission Tomography with Computed Tomography (PET/CT) has been proven to be useful in the definition of Radiotherapy (RT) target volume. In this regard, the present expert review summarizes existing data for pancreas, prostate, gynecological and rectum/anal cancer. METHODS: A comprehensive search of published original article was made, based on SCOPUS and PubMed database, selecting the paper that evaluated the role of PET/CT in the definition of RT volume. RESULTS: FDG-PET has an important and promising role for pancreatic cancer. Choline PET/CT could be useful for identifying high-risk volumes for prostate cancer; while PSMA PET/CT is still under evaluation. FDG PET/CT in gynecological cancers has been shown to impact external-beam RT planning. The role of FDG-PET for Gross Tumor volume identification is crucial, representing a useful and powerful tool for anal and rectal cancer. CONCLUSION: Taken together, molecular and functional imaging approaches offer a major step to individualize radiotherapeutic approach.
AIM: Positron Emission Tomography with Computed Tomography (PET/CT) has been proven to be useful in the definition of Radiotherapy (RT) target volume. In this regard, the present expert review summarizes existing data for pancreas, prostate, gynecological and rectum/anal cancer. METHODS: A comprehensive search of published original article was made, based on SCOPUS and PubMed database, selecting the paper that evaluated the role of PET/CT in the definition of RT volume. RESULTS: FDG-PET has an important and promising role for pancreatic cancer. Choline PET/CT could be useful for identifying high-risk volumes for prostate cancer; while PSMA PET/CT is still under evaluation. FDG PET/CT in gynecological cancers has been shown to impact external-beam RT planning. The role of FDG-PET for Gross Tumor volume identification is crucial, representing a useful and powerful tool for anal and rectal cancer. CONCLUSION: Taken together, molecular and functional imaging approaches offer a major step to individualize radiotherapeutic approach.
Authors: J Ristau; F L Giesel; M F Haefner; F Staudinger; T Lindner; A Merkel; J Schlittenhardt; C Kratochwil; P L Choyke; K Herfarth; J Debus; U Haberkorn; S A Koerber Journal: Mol Imaging Biol Date: 2020-10-15 Impact factor: 3.488
Authors: Clelia Di Carlo; Maika di Benedetto; Lisa Vicenzi; Sara Costantini; Francesca Cucciarelli; Francesco Fenu; Eleonora Arena; Cristina Mariucci; Maria Montisci; Valeria Panni; Fabiola Patani; Marco Valenti; Andrea Palucci; Luca Burroni; Giovanna Mantello Journal: Front Oncol Date: 2021-07-01 Impact factor: 6.244