Literature DB >> 3094007

Assignment of the human and mouse prion protein genes to homologous chromosomes.

R S Sparkes, M Simon, V H Cohn, R E Fournier, J Lem, I Klisak, C Heinzmann, C Blatt, M Lucero, T Mohandas.   

Abstract

Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious particles. The PrP gene was assigned to human chromosome 20 and the corresponding mouse chromosome 2 using somatic cell hybrids. In situ hybridization studies mapped the human PrP gene to band 20p12----pter. Our results should lead to studies of genetic loci syntenic with the PrP gene, which may play a role in the pathogenesis of prion diseases or other degenerative neurologic disorders.

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Year:  1986        PMID： 3094007      PMCID： PMC386716          DOI： 10.1073/pnas.83.19.7358

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

1.  SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.

Authors:  J W LITTLEFIELD
Journal:  Science       Date:  1964-08-14       Impact factor: 47.728

2.  Genetics of human cess line. IV. DNA-mediated heritable transformation of a biochemical trait.

Authors:  E H SZYBALSKA; W SZYBALSKI
Journal:  Proc Natl Acad Sci U S A       Date:  1962-12-15       Impact factor: 11.205

3.  Unconventional viruses and the origin and disappearance of kuru.

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Journal:  Science       Date:  1977-09-02       Impact factor: 47.728

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Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

5.  Ouabain as a selective agent in the isolation of somatic cell hybrids.

Authors:  R S Kucherlapati; R M Baker; F H Ruddle
Journal:  Cytogenet Cell Genet       Date:  1975

6.  Assignment of a gene for adenosine deaminase to human chromosome 20.

Authors:  J A Tischfield; R P Creagan; E A Nichols; F H Ruddle
Journal:  Hum Hered       Date:  1974       Impact factor: 0.444

7.  Linkage of prion protein and scrapie incubation time genes.

Authors:  G A Carlson; D T Kingsbury; P A Goodman; S Coleman; S T Marshall; S DeArmond; D Westaway; S B Prusiner
Journal:  Cell       Date:  1986-08-15       Impact factor: 41.582

8.  Improved techniques for the induction of mammalian cell hybridization by polyethylene glycol.

Authors:  R L Davidson; P S Gerald
Journal:  Somatic Cell Genet       Date:  1976-03

9.  Creutzfeldt-Jakob disease: patterns of worldwide occurrence and the significance of familial and sporadic clustering.

Authors:  C L Masters; J O Harris; D C Gajdusek; C J Gibbs; C Bernoulli; D M Asher
Journal:  Ann Neurol       Date:  1979-02       Impact factor: 10.422

10.  Chromosomal assignment and trans regulation of the tyrosine aminotransferase structural gene in hepatoma hybrid cells.

Authors:  T C Peterson; A M Killary; R E Fournier
Journal:  Mol Cell Biol       Date:  1985-09       Impact factor: 4.272
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  48 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 2.  Mouse chromosome 2.

Authors:  L D Siracusa; C M Abbott
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

3.  Alternate centromere inactivation in a pseudodicentric (15;20)(pter;pter) associated with a progressive neurological disorder.

Authors:  H Rivera; O Zuffardi; P Maraschio; A Caiulo; C Anichini; R Scarinci; R Vivarelli
Journal:  J Med Genet       Date:  1989-10       Impact factor: 6.318

4.  A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.

Authors:  H M Schätzl; L Laszlo; D M Holtzman; J Tatzelt; S J DeArmond; R I Weiner; W C Mobley; S B Prusiner
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

5.  Mad cow and other maladies: update on emerging infectious diseases.

Authors:  Cristie Columbus
Journal:  Proc (Bayl Univ Med Cent)       Date:  2004-10

Review 6.  Mouse chromosome 2.

Authors:  L D Siracusa; C M Abbott
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 7.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 8.  Prion liposomes.

Authors:  R Gabizon; S B Prusiner
Journal:  Biochem J       Date:  1990-02-15       Impact factor: 3.857

9.  Three-exon structure of the gene encoding the rat prion protein and its expression in tissues.

Authors:  K Saeki; Y Matsumoto; Y Hirota; Y Matsumoto; T Onodera
Journal:  Virus Genes       Date:  1996       Impact factor: 2.332

10.  Mutation and polymorphism of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease (CJD).

Authors:  R Gabizon; H Rosenmann; Z Meiner; I Kahana; E Kahana; Y Shugart; J Ott; S B Prusiner
Journal:  Am J Hum Genet       Date:  1993-10       Impact factor: 11.025
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